エキナセア抽出物の生理機能に関する研究

• Material Type: 博士論文
• Title: エキナセア抽出物の生理機能に関する研究
• Author/Editor: アヌ, ゾリグ
• Author Heading: アヌ, ゾリグ
• Publication Date: 2021-03
• Publication Date (W3CDTF): 2021-03
• Alternative Title: Study on biological functions of Echinacea purpurea extracts
• Pages: 1-
• Degree Grantor: 北見工業大学
• Date Granted: 2021-03-19
• Date Granted (W3CDTF): 2021-03-19
• Dissertation Number: 甲第188号
• Degree Type: 博士（工学）
• Conferring No. (Dissertation): 甲第188号
• Text Language Code: eng
• Subject Heading: Echinacea Purpurea; allergy; inflammation; mast cell; macrophage; polyphenols
• Target Audience: 一般
• DOI: 10.19000/0000009041; https://doi.org/10.19000/0000009041
• Persistent ID (NDL): info:ndljp/pid/12219141; https://dl.ndl.go.jp/pid/12219141
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2022-04-04T15:10:33+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): https://doi.org/10.19000/0000009041; https://kitami-it.repo.nii.ac.jp/records/9041
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

• Summary, etc.: Allergy is a disorder of immune response that is classified into several types according to the mechanism involved. Immediate hypersensitivities such as hay fever and food allergies are categorized as type-I allergies, in which mast cells and basophilic leukocytes play an important role in the allergic reaction. Allergens are presented by dendritic cells. These cytokines induce the differentiation and class switching of B cells, and they become IgE productive plasma cells. IgEs released from plasma cells and they bind to the surface of mast cells. When the allergen reacts with IgE, that is antigen-antibody reaction, mast cells immediately release the chemical mediators, which lead to allergic symptoms such as cough and runny nose. Mast cell is stimulated by the antigen-antibody reaction, signal transduction and the intracellular increase of Ca2+ are induced. Histamine stored in the cells is released by degranulation. Histamine causes smooth muscle contraction and the promotion of mucus secretion. On the other hand, when phospholipase A2 is activated, arachidonic acid is released from the biological membrane, and leukotrienes (LTs) are produced by 5-lipoxygenase and released. LTs promote the chronicity of allergic symptoms by migrating eosinophils to allergic reaction sites. Inflammation is a response of body tissues to pathogens, broken cells, or irritants, and is a protecting reaction related to immune cells, blood vessels, and molecular mediators. The chemical mediator launched in hypersensitivity or the like acts on blood vessels to boom blood glide and decorate vascular permeability. This promotes exudation of frame fluids and blood proteins, and neighborhood migration and infiltration of inflammatory cells which include neutrophils, lymphocytes, and macrophages. As a result, inflammatory signs and symptoms along with redness, heat, swelling, and pain are exhibited. Echinacea was used at length by Native Americans and by traditional herbalists in the United States, and in Canada. Many different medical conditions such as sore throat, swollen gum, gastrointestinal disorder were treated with Echinacea roots long ago by native Americans. The term Echinacea refers to several plants in the genus Echinacea. While there are nine known species of Echinacea, only the three of them, Echinacea purpurea, Echinacea angustifolia, and Echinacea pallida, are used as medicinal plants for the prevention and treatment of the common cold and influenza. Echinacea purpurea is a kind of herbaceous perennial flowering plant of Asteracea family, and it is widely distributed all over the world. Native Americans utilize its roots as medicine and European people have it for herb tea, also known as the purple coneflower. The functions are Echinacea polyphenols such as caffeic acid derivatives including chicoric acid, which are abundant in the roots. The objectives of this study are to elucidate the effects of anti-allergic and antiinflammation of Echinacea purpurea extracts in mast cells and macrophages.
• DOI: 10.19000/0000009041; https://doi.org/10.19000/0000009041
• Format (IMT): application/pdf
• Source: Study on biological functions of Echinacea purpurea extracts （fulltext）; https://kitami-it.repo.nii.ac.jp/record/9041/files/%E7%94%B2188_ANUU%20ZORIG.pdf
• Access Restrictions: インターネット公開
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 北見工業大学 : 北見工業大学学術機関リポジトリ KIT-R

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