Development of TX-816 and its derivatives as 5-Aminolevurinic acid-based photodynamic therapy sensitizer

Persistent ID (NDL): info:ndljp/pid/12219566

Material type: 博士論文

Author: 篠原, 侑成

Publisher: -

Publication date: 2021-03-23

Material Format: Digital

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Name of awarding university/degree: 徳島大学,博士（工学）

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Note (General)：: 5-Aminolevulinic acid (ALA), a precursor of protoporphyrin IX (PpIX), is now widely used for photodynamic therapy (ALA-PDT) of various cancers. Recent...

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Material Type: 博士論文
Title: Development of TX-816 and its derivatives as 5-Aminolevurinic acid-based photodynamic therapy sensitizer
Author/Editor: 篠原, 侑成
Author Heading: 篠原, 侑成
Publication Date: 2021-03-23
Publication Date (W3CDTF): 2021-03-23
Alternative Title: 5-アミノレブリン酸を用いた光線力学療法増感剤としてのTX-816及びその誘導体の開発
Degree grantor/type: 徳島大学
Date Granted: 2021-03-23
Date Granted (W3CDTF): 2021-03-23
Dissertation Number: 甲第3514号
Degree Type: 博士（工学）
Conferring No. (Dissertation): 甲第3514号
Text Language Code: eng
Subject Heading: 5-Aminolevulinic acid
Protoporphyrin IX
Photodynamic therapy
Schiff base
Target Audience: 一般
Note (General): 5-Aminolevulinic acid (ALA), a precursor of protoporphyrin IX (PpIX), is now widely used for photodynamic therapy (ALA-PDT) of various cancers. Recently, I found that treatment of cancer cells with the Schiff base derivative TX-816 along with ALA could significantly increase the efficacy of ALA-PDT. This enhancing effect of TX-816 on ALA-PDT is attributed to 3,5-dichlorosalicylaldehyde (DCSA), a molecule produced by the degradation of TX-816. Similar to TX-816, DCSA significantly enhances the effect of ALA-PDT. Furthermore, DCSA could restore the sensitivity of cancer cells that acquired resistance to ALA-PDT. These results indicate that DCSA, as well as TX-816, is a potent lead compound for the development of an ALA-PDT sensitizer.
Persistent ID (NDL): info:ndljp/pid/12219566
https://dl.ndl.go.jp/pid/12219566
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
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Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-04-04T15:10:33+09:00
Format (IMT): application/pdf
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Availability of remote photoduplication service: 可
Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/115991
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