Telomerase reverse transcriptase promoter mutations in human hepatobiliary, pancreatic and gastrointestinal cancer cell lines

Persistent ID (NDL): info:ndljp/pid/12263387

Material type: 博士論文

Author: 小野, 正大

Publisher: -

Publication date: 2022-03-24

Material Format: Digital

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Name of awarding university/degree: 香川大学,博士（医学）

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Note (General)：: Background/aim: The promoter region of the telomerase reverse transcriptase (TERT) gene is a regulatory element capable of affecting TERT expression, ...

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Material Type: 博士論文
Title: Telomerase reverse transcriptase promoter mutations in human hepatobiliary, pancreatic and gastrointestinal cancer cell lines
Author/Editor: 小野, 正大
Author Heading: 小野, 正大
Publication Date: 2022-03-24
Publication Date (W3CDTF): 2022-03-24
Alternative Title: 消化器系統癌細胞株を用いたTERTプロモーター点変異の網羅的解析
Degree grantor/type: 香川大学
Date Granted: 2022-03-24
Date Granted (W3CDTF): 2022-03-24
Dissertation Number: 甲第803号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第803号
Text Language Code: eng
Alias of Author: Ono, Masahiro
平田, 正大
Subject Heading: TERT
telomerase
hepatobiliary
gastrointestinal
cancer
digital PCR
TERT promoter C228T
TERT promoter C250T
Target Audience: 一般
Note (General): Background/aim: The promoter region of the telomerase reverse transcriptase (TERT) gene is a regulatory element capable of affecting TERT expression, telomerase activity, and telomerase length. Mutations within the TERT promoter region are the most common mutations in many cancers. In this study, we characterized the TERT promoter mutation status in hepatobiliary, pancreatic, and gastrointestinal cancer cell lines.
Materials and methods: TERT promoter mutation status was assessed by digital PCR in 12 liver cancer, 5 cholangiocarcinoma (CCA), 12 pancreatic cancer, 17 gastrointestinal cancer, and 3 healthy control cell lines.
Results: The C228T promoter mutation was detected in 9 liver cancer lines, and the C250T TERT mutation was detected in 1 oesophageal squamous cell carcinoma line.
Conclusion: The C228T promoter mutation is specific to liver cancer cell lines among various gastrointestinal cancer cell lines. These data will contribute to future research on the tumorigenic mechanisms and clinical use of digital PCR to detect mutations.
DOI: info:doi/10.21873/invivo.12680
https://doi.org/info:doi/10.21873/invivo.12680
Persistent ID (NDL): info:ndljp/pid/12263387
https://dl.ndl.go.jp/pid/12263387
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-05-09T11:57:37+09:00
Date Created (W3CDTF): 2022-04-21
Format (IMT): PDF
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): https://kagawa-u.repo.nii.ac.jp/records/9555
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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