Luseogliflozin, a SGLT2 inhibitor, does not affect glucose uptake kinetics in renal proximal tubules of live mice

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Luseogliflozin, a SGLT2 inhibitor, does not affect glucose uptake kinetics in renal proximal tubules of live mice

Persistent ID (NDL): info:ndljp/pid/12263391

Material type: 博士論文

Author: 張, 安琦

Publisher: -

Publication date: 2022-03-24

Material Format: Digital

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Name of awarding university/degree: 香川大学,博士（医学）

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Note (General)：: Proximal tubules (PTs) take up most of the glucose in the glomerular filtrate and return it to peritubular capillary blood. Sodium-glucose cotransport...

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Material Type: 博士論文
Title: Luseogliflozin, a SGLT2 inhibitor, does not affect glucose uptake kinetics in renal proximal tubules of live mice
Author/Editor: 張, 安琦
Author Heading: 張, 安琦
Publication Date: 2022-03-24
Publication Date (W3CDTF): 2022-03-24
Alternative Title: SGLT2阻害薬であるルセオグリフロジンは、生きているマウスの腎近位尿細管におけるグルコース取り込み動態に影響を与えない
Degree grantor/type: 香川大学
Date Granted: 2022-03-24
Date Granted (W3CDTF): 2022-03-24
Dissertation Number: 甲第799号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第799号
Text Language Code: eng
Alias of Author: 张, 安琦
Subject Heading: glucose handling
proximal tubules
intravital imaging
Target Audience: 一般
Note (General): Proximal tubules (PTs) take up most of the glucose in the glomerular filtrate and return it to peritubular capillary blood. Sodium-glucose cotransporter 2 (SGLT2) at the apical membrane takes up glucose into the cell. Glucose then flows across the cells and is transported to the interstitium via glucose transporter 2 (GLUT2) at the basolateral membrane. However, glucose transport under SGLT2 inhibition remains poorly understood. In this study, we evaluated the dynamics of a fluorescent glucose analog, 2-NBDG, in the PTs of live mice treated with or without the SGLT2 inhibitor, luseogliflozin. We employed real-time multiphoton microscopy, in which insulin enhanced 2-NBDG uptake in skeletal muscle. Influx and efflux of 2-NBDG in PT cells were compared under hypo-, normo-, and hyperglycemic conditions. Luseogliflozin did not exert significant effects on glucose influx parameters under any level of blood glucose. Our results suggest that blood glucose level per se does not alter glucose influx or efflux kinetics in PTs. In conclusion, neither SGLT2 inhibition nor blood glucose level affect glucose uptake kinetics in PTs. The former was because of glucose influx through basolateral GLUT2, which is an established bidirectional transporter.
DOI: info:doi/10.3390/ijms22158169
https://doi.org/info:doi/10.3390/ijms22158169
Persistent ID (NDL): info:ndljp/pid/12263391
https://dl.ndl.go.jp/pid/12263391
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-05-09T11:57:37+09:00
Date Created (W3CDTF): 2022-04-21
Format (IMT): PDF
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): https://kagawa-u.repo.nii.ac.jp/records/9550
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp