Association between serum IgG antibody titers against Porphyromonas gingivalis and liver enzyme levels : A cross-sectional study in Sado Island

• Material Type: 博士論文
• Title: Association between serum IgG antibody titers against Porphyromonas gingivalis and liver enzyme levels : A cross-sectional study in Sado Island
• Author/Editor: Takamisawa, Kei
• Author Heading: Takamisawa, Kei
• Publication Date: 2021-03-23
• Publication Date (W3CDTF): 2021-03-23
• Alternative Title: 血清抗Porphyromonas gingivalis IgG抗体価と血清肝機能マーカー値との関連性 : 新潟県佐渡市における横断研究
• Degree grantor/type: 新潟大学
• Date Granted: 2021-03-23
• Date Granted (W3CDTF): 2021-03-23
• Dissertation Number: 甲第4870号
• Degree Type: 博士（歯学）
• Conferring No. (Dissertation): 甲第4870号
• Text Language Code: eng
• Alias of Author: 髙見澤, 圭
• Subject Heading: Clinical research; Dentistry; Hepatobiliary system; Internal medicine; Liver enzymes; Periodontitis; Obesity; Porphyromonas gingivalis; Antibody
• Target Audience: 一般
• Note (General): Background: Previous studies have reported associations between nonalcoholic fatty liver disease, periodontitis, and obesity. Serum immunoglobulin G (IgG) antibody titer against Porphyromonas gingivalis, a major pathogen of periodontitis, is an established indicator of periodontal infection. However, the relationship between the antibody titer and liver enzyme levels has not been clarified yet. A study in the elderly was needed to evaluate the effect of long-term persistent bacterial infection on liver function. The objective of this study was to investigate the association between liver function and infection by P. gingivalis, and the effect of obesity on the association. Methods: A cross-sectional study was conducted in adult outpatients visiting Sado General Hospital, in Niigata Prefecture, Japan, from 2008 to 2010. The final participants included 192 men and 196 women (mean age 68.1 years). Multivariable logistic regression analyses were performed to assess the association between the serum IgG antibody titer and the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and γ-glutamine transferase (GGT) levels. Results: In women, serum IgG antibody titers against P. gingivalis was associated with elevated ALT, but not with AST or GGT, independent of covariates (p = 0.015). No significant association was found between the antibody titer and the elevated liver enzymes in men. The effect of obesity on the relationship between antibody titer and liver enzyme levels was not statistically significant. Conclusions: A cross-sectional analysis of adult outpatients suggested an association between P. gingivalis infection and ALT levels in women. The effect of obesity on this association was not statistically significant.; Heliyon, 2020, 6(11), e05531.; 新大院博(歯)第478号
• Persistent ID (NDL): info:ndljp/pid/12263514; https://dl.ndl.go.jp/pid/12263514
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2022-05-09T11:57:37+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
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• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10191/0002000366; https://niigata-u.repo.nii.ac.jp/records/2000366
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp