The clinical significance of distal spread differs according to the primary tumor location in rectal cancer

Persistent ID (NDL): info:ndljp/pid/12263729

Material type: 博士論文

Author: Abe, Kaoru

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Publication date: 2021-03-23

Material Format: Digital

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Name of awarding university/degree: 新潟大学,博士（医学）

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Note (General)：: Purpose Treatment strategies of rectal cancer differ between tumors located above (RS/Ra) and below (Rb) the peritoneal reflection. Based on the exten...

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Material Type: 博士論文
Title: The clinical significance of distal spread differs according to the primary tumor location in rectal cancer
Author/Editor: Abe, Kaoru
Author Heading: Abe, Kaoru
Publication Date: 2021-03-23
Publication Date (W3CDTF): 2021-03-23
Alternative Title: 直腸癌における肛門側癌進展の臨床的意義は原発巣の局在により異なる
Degree grantor/type: 新潟大学
Date Granted: 2021-03-23
Date Granted (W3CDTF): 2021-03-23
Dissertation Number: 甲第4852号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第4852号
Text Language Code: eng
Alias of Author: 阿部, 馨
Subject Heading: Distal spread
Rectal cancer
Whole-mount section
Clinical significance
Target Audience: 一般
Note (General): Purpose Treatment strategies of rectal cancer differ between tumors located above (RS/Ra) and below (Rb) the peritoneal reflection. Based on the extent of distal spread (DS), the Japanese Society for Cancer of Colon and Rectum proposed an optimal distal margin in RS/Ra and Rb tumors. In this study, we investigated the clinical significance of DS between RS/Ra and Rb tumors. Methods We analyzed 287 stage I–III rectal cancer patients who underwent curative intent resection without preoperative therapy. DS and other pathological factors were evaluated using whole-mount sections. To investigate the clinical significance of DS in RS/Ra and Rb tumors, clinicopathological variables, including DS, were analyzed for the survival outcome according to the tumor group. Results DS was detected in 20 out of 185 (11%) patients with RS/Ra tumors and 8 out of 102 (8%) patients with Rb tumors. DS was not significantly associated with the overall survival (OS) or relapse-free survival (RFS) in RS/Ra tumors, but was an independent prognostic factor for the OS and RFS in Rb tumors (P = 0.002 and 0.007, respectively). Conclusions The clinical significance of DS differs between RS/Ra and Rb tumors. DS is associated with a worse survival in Rb tumors, but not in RS/Ra tumors.
Surgery Today. 2020, 50(4), 360–368.
新大院博(医)第1006号
Persistent ID (NDL): info:ndljp/pid/12263729
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Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
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Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-05-09T11:57:37+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
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Availability of remote photoduplication service: 可
Periodical Title (URI): http://hdl.handle.net/10191/0002000311
https://niigata-u.repo.nii.ac.jp/records/2000311
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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