Effects of DPP-4 Inhibitors on Blood Glucose Variability in Japanese Patients with Type 2 Diabetes on Maintenance Hemodialysis : A Prospective Observational Exploratory Study

• Material Type: 博士論文
• Title: Effects of DPP-4 Inhibitors on Blood Glucose Variability in Japanese Patients with Type 2 Diabetes on Maintenance Hemodialysis : A Prospective Observational Exploratory Study
• Author/Editor: Ishikawa-Tanaka, Tomomi
• Author Heading: Ishikawa-Tanaka, Tomomi
• Publication Date: 2021-03-23
• Publication Date (W3CDTF): 2021-03-23
• Alternative Title: 日本人2型糖尿病維持透析患者におけるDPP-4阻害薬の血糖変動に与える影響 : 前向き観察研究
• Degree grantor/type: 新潟大学
• Date Granted: 2021-03-23
• Date Granted (W3CDTF): 2021-03-23
• Dissertation Number: 甲第4831号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第4831号
• Text Language Code: eng
• Alias of Author: 田中, 友美
• Subject Heading: Blood glucose variability; Continuous glucose monitoring; DPP-4 inhibitors; Hemodialysis; Hypoglycemia
• Target Audience: 一般
• Note (General): Introduction: The precise blood glucose (BG) profile of hemodialysis patients is unclear, as is the effectiveness of dipeptidyl peptidase-4 (DPP-4) inhibitors in hemodialysis patients with type 2 diabetes. Here, we used continuous glucose monitoring (CGM) to evaluate BG variability in these patients and to assess the efficacy of DPP-4 inhibitors, particularly during hemodialysis sessions and at nighttime (UMIN000012638). Methods: We examined BG profiles using CGM in 31 maintenance hemodialysis patients with type 2 diabetes. Differences between patients with and without DPP-4 inhibitors (n = 15 and 16, respectively) were analyzed using a linear mixed-effects model to assess changes in glucose levels in 5-min intervals. Results: The model revealed that DPP-4 inhibitor use was significantly associated with suppression of a rapid drop in glucose levels, both with and without adjustment for BG levels at the start of hemodialysis. Moreover, the model revealed that the two groups differed significantly in the pattern of changes in BG levels from 0:00 to 6:55 am. DPP-4 inhibitors suppressed the tendency for subsequent nocturnal hypoglycemia. Conclusions: This prospective observational exploratory study showed that DPP-4 inhibitors could suppress BG variability during hemodialysis sessions as well as subsequent nocturnal changes in patients with type 2 diabetes.; Diabetes Therapy. 2020, 11(12), 2845–2861.; 新大院博(医)第985号
• Persistent ID (NDL): info:ndljp/pid/12263746; https://dl.ndl.go.jp/pid/12263746
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2022-05-09T11:57:37+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10191/0002000290; https://niigata-u.repo.nii.ac.jp/records/2000290
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp