Generation of thyroid tissues from embryonic stem cell via blastocyst complementation in vivo

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Generation of thyroid tissues from embryonic stem cell via blastocyst complementation in vivo

Persistent ID (NDL): info:ndljp/pid/12263750

Material type: 博士論文

Author: Ran, Qingsong

Publisher: -

Publication date: 2021-03-23

Material Format: Digital

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Name of awarding university/degree: 新潟大学,博士（医学）

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Note (General)：: The generation of mature, functional, thyroid follicular cells from pluripotent stem cells would potentially provide a therapeutic benefit for patient...

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Material Type: 博士論文
Title: Generation of thyroid tissues from embryonic stem cell via blastocyst complementation in vivo
Author/Editor: Ran, Qingsong
Author Heading: Ran, Qingsong
Publication Date: 2021-03-23
Publication Date (W3CDTF): 2021-03-23
Alternative Title: 胚盤胞補完法とES細胞を用いたマウス生体内における甲状腺再生
Degree grantor/type: 新潟大学
Date Granted: 2021-03-23
Date Granted (W3CDTF): 2021-03-23
Dissertation Number: 甲第4827号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第4827号
Text Language Code: eng
Alias of Author: 冉, 慶松
Subject Heading: blastocyst complementation
embryonic stem cells
Fgf10
pluripotent stem cells
thyroid generation
Target Audience: 一般
Note (General): The generation of mature, functional, thyroid follicular cells from pluripotent stem cells would potentially provide a therapeutic benefit for patients with hypothyroidism, but in vitro differentiation remains difficult. We earlier reported the in vivo generation of lung organs via blastocyst complementation in fibroblast growth factor 10 (Fgf10), compound, heterozygous mutant (Fgf10 Ex1^<mut>/Ex3^<mut>) mice. Fgf10 also plays an essential role in thyroid development and branching morphogenesis but any role thereof in thyroid organogenesis remains unclear. Here, we report that the thyroids of Fgf10 Ex1^<mut>/Ex3^<mut> mice exhibit severe hypoplasia and we generate thyroid tissues from mouse embryonic stem cells (ESCs) in Fgf10 Ex1^<mut>/Ex3^<mut> mice via blastocyst complementation. The tissues were morphologically normal and physiologically functional. The thyroid follicular cells of Fgf10 Ex1^<mut>/Ex3^<mut> chimeric mice were derived largely from GFP-positive mouse ESCs although the recipient cells were mixed. Thyroid generation in vivo via blastocyst complementation will aid functional thyroid regeneration.
Front. Endocrinol. 2020, 11, 609697.
新大院博(医)第981号
Persistent ID (NDL): info:ndljp/pid/12263750
https://dl.ndl.go.jp/pid/12263750
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-05-09T11:57:37+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://hdl.handle.net/10191/0002000286
https://niigata-u.repo.nii.ac.jp/records/2000286
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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