A Comparative Study of High-dose-rate Brachytherapy Boost Combined with External Beam Radiation Therapy Versus External Beam Radiation Therapy Alone for High-risk Prostate Cancer

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A Comparative Study of High-dose-rate Brachytherapy Boost Combined with External Beam Radiation Therapy Versus External Beam Radiation Therapy Alone for High-risk Prostate Cancer

Persistent ID (NDL): info:ndljp/pid/12263752

Material type: 博士論文

Author: Oshikane, Tomoya

Publisher: -

Publication date: 2021-03-23

Material Format: Digital

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Name of awarding university/degree: 新潟大学,博士（医学）

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Note (General)：: We aimed to compare the outcomes of high-dose-rate brachytherapy (HDR-BT) boost and external beam radiation therapy (EBRT) alone for high-risk prostat...

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Material Type: 博士論文
Title: A Comparative Study of High-dose-rate Brachytherapy Boost Combined with External Beam Radiation Therapy Versus External Beam Radiation Therapy Alone for High-risk Prostate Cancer
Author/Editor: Oshikane, Tomoya
Author Heading: Oshikane, Tomoya
Publication Date: 2021-03-23
Publication Date (W3CDTF): 2021-03-23
Alternative Title: 高リスク前立腺癌に対する外照射併用高線量率組織内照射と外照射単独の比較検討
Degree grantor/type: 新潟大学
Date Granted: 2021-03-23
Date Granted (W3CDTF): 2021-03-23
Dissertation Number: 甲第4825号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第4825号
Text Language Code: eng
Alias of Author: 押金, 智哉
Subject Heading: high-dose-rate brachytherapy
intensity-modulated radiation therapy
prostate cancer
biochemical-free survival
Target Audience: 一般
Note (General): We aimed to compare the outcomes of high-dose-rate brachytherapy (HDR-BT) boost and external beam radiation therapy (EBRT) alone for high-risk prostate cancer. This was a single-center, retrospective, and observational study. Consecutive patients who underwent initial radical treatment by HDR-BT boost or EBRT alone from June 2009 to May 2016 at the Niigata University Medical and Dental Hospital, Japan were included. A total of 96 patients underwent HDR-BT boost, and 61 underwent EBRT alone. The prescription dose of HDR-BT boost was set to 18 Gy/2 times/day with EBRT 39 Gy/13 fractions. The dose for EBRT alone was mostly 70 Gy/28 fractions. The high-risk group received >6 months of prior androgen deprivation therapy. Overall survival, biochemical-free survival, local control, and distant metastasis-free survival rates at 5 years were analyzed. The incidence of urological and gastrointestinal late adverse events of G2 and above was also summarized. In the National Comprehensive Cancer Network (NCCN) high-risk, HDR-BT boost had a significantly higher biochemical-free survival rate at 5 years (98.9% vs 90.7%, p = 0.04). Urethral strictures were more common in the HDR-BT boost group. We will continuously observe the progress of the study patients and determine the longer-term results.
Journal of Radiation Research. 2021, 62(3), 525–532.
新大院博(医)第979号
Persistent ID (NDL): info:ndljp/pid/12263752
https://dl.ndl.go.jp/pid/12263752
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-05-09T11:57:37+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://hdl.handle.net/10191/0002000284
https://niigata-u.repo.nii.ac.jp/records/2000284
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp