Dendritic Cells Directly Recognize Nickel Ions as an Antigen during the Development of Nickel Allergy 2

• Material Type: 博士論文
• ISSN: 2189-6682
• Title: Dendritic Cells Directly Recognize Nickel Ions as an Antigen during the Development of Nickel Allergy
• Volume: 34 2
• Author/Editor: Liu, Lipei; Watanabe, Megumi; Minami, Norikazu; Yunizar, Mohammad Fadyl; Ichikawa, Tetsuo
• Author Heading: Liu, Lipei; Watanabe, Megumi; Minami, Norikazu; Yunizar, Mohammad Fadyl; Ichikawa, Tetsuo
• Publication, Distribution, etc.: 四国歯学会
• Publication Date: 2022-03-06
• Publication Date (W3CDTF): 2022-03-06
• Alternative Title: 樹状細胞はニッケルアレルギーの発症時にニッケルイオンを抗原として直接認識する
• Periodical title: Journal of Oral Health and Biosciences
• Degree grantor/type: 徳島大学
• Date Granted: 2022-03-10
• Date Granted (W3CDTF): 2022-03-10
• Dissertation Number: 甲第3586号
• Degree Type: 博士（歯学）
• Conferring No. (Dissertation): 甲第3586号
• Text Language Code: eng
• Subject Heading: Metal allergy; Nickel ions; Phagocytosis; Dendritic cell migration
• Target Audience: 一般
• Note (General): Metal hypersensitivity, a disorder of the immune system, typically manifests as contact hypersensitivity to metals during daily contact. The molecular mechanism whereby metals enter the body and cause allergic disorders remains elusive. It is thought that eluted metal ions are captured by dendritic cells (DCs) and transferred to the draining lymph nodes to activate T cells. Here, for the first time, we used a metal indicator Newport Green to locate the most common allergenic metal, nickel (Ni) ions, captured by DCs and transferred to lymph nodes. Capturing Ni ions did not affect the activity of DCs. Ni ions entered DCs and showed positive staining in keratinocytes. A time varied quantitative analysis demonstrated that at 1 h, a small amount of Ni ions was observed in the epidermal sheet. After 6 h, the number of Ni ions that entered the epidermal sheet reached a peak and remained constant for a few days and were gradually emitted 48 h later. In the cervical lymph nodes of mice, accumulation of Ni ions reached a peak within 24 h and then gradually decreased. The findings of this study will contribute to the development of effective diagnoses and treatment methods for patients allergic to Ni.
• DOI: info:doi/10.20738/johb.34.2_40; https://doi.org/info:doi/10.20738/johb.34.2_40
• Persistent ID (NDL): info:ndljp/pid/12263867; https://dl.ndl.go.jp/pid/12263867
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2022-05-09T11:57:37+09:00
• Format (IMT): PDF
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/116784
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp