Predictive value of tumor-infiltrating lymphocytes for pathological response to neoadjuvant chemotherapy in breast cancer patients with axillary lymph node metastasis.

• Material Type: 博士論文
• ISSN: 0941-1291
• Title: Predictive value of tumor-infiltrating lymphocytes for pathological response to neoadjuvant chemotherapy in breast cancer patients with axillary lymph node metastasis.
• Volume: 51 4
• Author/Editor: Yokotani, Tomoyo; Ikeda, Naoya; Hirao, Tomoko; Tanaka, Yukimi; Morita, Kohei; Fujii, Tomomi; Ohbayashi, Chiho; Nakamura, Takashi; Kobayashi, Toyoki; Sho, Masayuki
• Author Heading: Yokotani, Tomoyo; Ikeda, Naoya; Hirao, Tomoko; Tanaka, Yukimi; Morita, Kohei; Fujii, Tomomi; Ohbayashi, Chiho; Nakamura, Takashi; Kobayashi, Toyoki; Sho, Masayuki
• Publication, Distribution, etc.: Springer Nature
• Publication Date: 2021-04; 51 4
• Publication Date (W3CDTF): 2021-04
• Alternative Title: 乳癌術前化学療法において腋窩リンパ節転移が陰性化するための効果予測因子の検討
• Periodical title: Surgery today
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2021-03-15
• Date Granted (W3CDTF): 2021-03-15
• Dissertation Number: 乙第1498号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 乙第1498号
• Text Language Code: eng
• Subject Heading: Tumor-infiltrating lymphocytes; Axillary dissection; Breast cancer; Neoadjuvant chemotherapy; Axillary pathological complete response
• Target Audience: 一般
• Note (General): type:Thesis; Purpose: We investigated the role of tumor-infiltrating lymphocytes (TILs) in pretreatment primary breast cancer to predict pathological response to neoadjuvant chemotherapy (NAC) in patients with clinical node-positive disease (cN +). Methods: The subjects of this study were 60 patients with cN + , who received NAC followed by breast surgery with axillary lymph node dissection (ALND). We conducted a semi-quantitative assessment of TILs in pretreatment primary tumors and their association with clinicopathological factors and axillary lymph node metastasis. Results: We observed a higher number of TILs in tumors with negative hormone receptors, positive human epidermal growth factor receptor 2, or high Ki67. TILs were associated with a favorable response to NAC in primary tumors. The rate of axillary pathologic complete response (Ax-pCR) was significantly higher in patients with a high number of TILs than in patients with a low number of TILs (72.0% versus 17.1%, p < 0.001). In multivariable analysis, a high number of TILs was a significant predictor of Ax-pCR as well as of pCR of the primary tumor after NAC. Importantly, all patients with HER2-positive tumors in the high TILs group showed Ax-pCR on ALND. Conclusion: TILs in pretreatment primary breast cancer had the potential to predict therapeutic efficacy of NAC in patients with clinical node-positive disease.; 博士（医学）・乙第1498号・令和3年3月15日; © Springer Nature Singapore Pte Ltd. 2020; This is a post-peer-review, pre-copyedit version of an article published in Surgery today. The final authenticated version is available online at: https://doi.org/10.1007/s00595-020-02157-6.; identifier:Surgery today Vol.51 No.4 p.595-604 (2021 Apr); identifier:09411291; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3924; identifier:Surgery today, 51(4): 595-604
• DOI: info:doi/10.1007/s00595-020-02157-6; https://doi.org/info:doi/10.1007/s00595-020-02157-6
• Persistent ID (NDL): info:ndljp/pid/12263877; https://dl.ndl.go.jp/pid/12263877
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2022-05-09T11:57:37+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10564/3924
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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