Prognostic value of partial EMT‐related genes in head and neck squamous cell carcinoma by a bioinformatic analysis 26 6

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Prognostic value of partial EMT‐related genes in head and neck squamous cell carcinoma by a bioinformatic analysis

Persistent ID (NDL): info:ndljp/pid/12263976

Material type: 博士論文

Author: Kisoda, Satoruほか

Publisher: John Wiley & Sons

Publication date: 2020-04-11

Material Format: Digital

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Name of awarding university/degree: 徳島大学,博士（歯学）

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Note (General)：: Objective: Recent studies have revealed that the ability of cancer cells to undergo intermediate state of EMT, partial EMT (p-EMT) poses a higher meta...

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Material Type: 博士論文
ISSN: 1601-0825
Title: Prognostic value of partial EMT‐related genes in head and neck squamous cell carcinoma by a bioinformatic analysis
Volume: 26 6
Author/Editor: Kisoda, Satoru
Shao, Wenhua
Fujiwara, Natsumi
Mouri, Yasuhiro
Tsunematsu, Takaaki
Jin, Shengjian
Arakaki, Rieko
Ishimaru, Naozumi
Kudo, Yasusei
Author Heading: Kisoda, Satoru
Shao, Wenhua
Fujiwara, Natsumi
Mouri, Yasuhiro
Tsunematsu, Takaaki
Jin, Shengjian
Arakaki, Rieko
Ishimaru, Naozumi
Kudo, Yasusei
Publication, Distribution, etc.: John Wiley & Sons
Publication Date: 2020-04-11
Publication Date (W3CDTF): 2020-04-11
Alternative Title: 部分的上皮間葉転換関連遺伝子による頭頚部扁平上皮癌の予後予測
Prognostic value of partial-EMT-related genes in head and neck squamous cell carcinoma by a bioinformatic analysis
Prognostic value of p-EMT-related genes in HNSCC
Periodical title: Oral Diseases
Degree grantor/type: 徳島大学
Date Granted: 2022-03-23
Date Granted (W3CDTF): 2022-03-23
Dissertation Number: 甲第3611号
Degree Type: 博士（歯学）
Conferring No. (Dissertation): 甲第3611号
Text Language Code: eng
Subject Heading: Head and neck squamous cell carcinoma
Partial-epithelial-to-mesenchymal transition
prognosis
Target Audience: 一般
Note (General): Objective: Recent studies have revealed that the ability of cancer cells to undergo intermediate state of EMT, partial EMT (p-EMT) poses a higher metastatic risk rather than complete EMT. Here we examined the prognostic value of p-EMT-related genes in head and neck squamous cell carcinoma (HNSCC) by bioinformatics approaches.Materials and Methods: We used RNA-seq data of 519 primary HNSCC cases obtained from TCGA database. We compared the expression of p-EMT-related genes in HNSCC tissues with normal tissues. We evaluated the prognostic value of p-EMT-related genes in HNSCC cases by Log-rank test. We examined the expression of p-EMT-, EMT-, and epithelial differentiation-related genes by qPCR.Results: Among p-EMT-related genes that were highly expressed in HNSCC cases, high expression of SERPINE1, ITGA5, TGFBI, P4HA2, CDH13, and LAMC2 was significantly correlated with poor survival of HNSCC patients. By gene expression pattern, HNSCC cell lines were classified into three groups; epithelial phenotype, EMT-phenotype, and p-EMT phenotype.Conclusions: Our findings suggest that p-EMT program may be involved in poor prognosis of HNSCC. SERPINE1, ITGA5, TGFBI, P4HA2, CDH13, and LAMC2 can be used for a prognostic marker. Moreover, HNSCC cells with p-EMT phenotype can be a useful model for investigating a nature of p-EMT.
DOI: info:doi/10.1111/odi.13351
https://doi.org/info:doi/10.1111/odi.13351
Persistent ID (NDL): info:ndljp/pid/12263976
https://dl.ndl.go.jp/pid/12263976
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-05-09T11:57:37+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/114969
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp