Fibroblast growth factor 2 suppresses the expression of C-C motif chemokine 11 through the c-Jun N-terminal kinase pathway in human dental pulp-derived mesenchymal stem cells 22 6

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Fibroblast growth factor 2 suppresses the expression of C-C motif chemokine 11 through the c-Jun N-terminal kinase pathway in human dental pulp-derived mesenchymal stem cells

Persistent ID (NDL): info:ndljp/pid/12296360

Material type: 博士論文

Author: Kurogoushi, Rikaほか

Publisher: Spandidos Publications

Publication date: 2021-09-24

Material Format: Digital

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Name of awarding university/degree: 徳島大学,博士（歯学）

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Note (General)：: The regulation of the mesenchymal stem cell (MSC) programming mechanism promises great success in regenerative medicine. Tissue regeneration has been ...

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Material Type: 博士論文
ISSN: 1792-0981
Title: Fibroblast growth factor 2 suppresses the expression of C-C motif chemokine 11 through the c-Jun N-terminal kinase pathway in human dental pulp-derived mesenchymal stem cells
Volume: 22 6
Author/Editor: Kurogoushi, Rika
Hasegawa, Tomokazu
Akazawa, Yuki
Iwata, Kokoro
Sugimoto, Asuna
Yamaguchi-Ueda, Kimiko
Miyazaki, Aya
Narwidina, Anrizandy
Kawarabayashi, Keita
Kitamura, Takamasa
Nakagawa, Hiroshi
Iwasaki, Tomonori
Iwamoto, Tsutomu
Author Heading: Kurogoushi, Rika
Hasegawa, Tomokazu
Akazawa, Yuki
Iwata, Kokoro
Sugimoto, Asuna
Yamaguchi-Ueda, Kimiko
Miyazaki, Aya
Narwidina, Anrizandy
Kawarabayashi, Keita
Kitamura, Takamasa
Nakagawa, Hiroshi
Iwasaki, Tomonori
Iwamoto, Tsutomu
Publication, Distribution, etc.: Spandidos Publications
Publication Date: 2021-09-24
Publication Date (W3CDTF): 2021-09-24
Alternative Title: FGF2はヒト歯髄由来間葉系幹細胞においてJNK経路を介してCCL11の発現を抑制する
FGF2 SUPPRESSED CCL11 EXPRESSION IN HUMAN DENTAL PULP-DERIVED MSCs
Periodical title: Experimental and Therapeutic Medicine
Degree grantor/type: 徳島大学
Date Granted: 2022-03-23
Date Granted (W3CDTF): 2022-03-23
Dissertation Number: 甲第3615号
Degree Type: 博士（歯学）
Conferring No. (Dissertation): 甲第3615号
Text Language Code: eng
Subject Heading: dental pulp-derived mesenchymal stem cells
fibroblast growth factor 2
fibroblast growth factor receptor signal
C-C motif ligand 11
c-Jun N-terminal kinase
Target Audience: 一般
Note (General): The regulation of the mesenchymal stem cell (MSC) programming mechanism promises great success in regenerative medicine. Tissue regeneration has been associated not only with the differentiation of MSCs, but also with the microenvironment of the stem cell niche that involves various cytokines and immune cells in the tissue regeneration site. In the present study, fibroblast growth factor 2 (FGF2), the principal growth factor for tooth development, dental pulp homeostasis and dentin repair, was reported to affect the expression of cytokines in human dental pulp‑derived MSCs. FGF2 significantly inhibited the expression of chemokine C‑C motif ligand 11 (CCL11) in a time‑ and dose‑dependent manner in the SDP11 human dental pulp‑derived MSC line. This inhibition was diminished following treatment with the AZD4547 FGF receptor (FGFR) inhibitor, indicating that FGF2 negatively regulated the expression of CCL11 in SDP11 cells. Furthermore, FGF2 activated the phosphorylation of p38 mitogen‑activated protein kinase (p38 MAPK), extracellular signal‑regulated kinase 1/2 (ERK1/2) and c‑Jun N‑terminal kinases (JNK) in SDP11 cells. The mechanism of the FGFR‑downstream signaling pathway was then studied using the SB203580, U0126 and SP600125 inhibitors for p38 MAPK, ERK1/2, and JNK, respectively. Interestingly, only treatment with SP600125 blocked the FGF2‑mediated suppression of CCL11. The present results suggested that FGF2 regulated the expression of cytokines and suppressed the expression of CCL11 via the JNK signaling pathway in human dental pulp‑derived MSCs. The present findings could provide important insights into the association of FGF2 and CCL11 in dental tissue regeneration therapy.
DOI: info:doi/10.3892/etm.2021.10791
https://doi.org/info:doi/10.3892/etm.2021.10791
Persistent ID (NDL): info:ndljp/pid/12296360
https://dl.ndl.go.jp/pid/12296360
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-06-05T18:01:14+09:00
Format (IMT): PDF
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/117039
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp