Metal Allergy Mediates the Development of Oral Lichen Planus via TSLP-TSLPR Signaling

Persistent ID (NDL): info:ndljp/pid/12296361

Material type: 博士論文

Author: Yunizar, Mohammad Fadylほか

Publisher: MDPI

Publication date: 2022-01-20

Material Format: Digital

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Name of awarding university/degree: 徳島大学,博士（歯学）

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Note (General)：: Metal allergy is a T-cell-mediated delayed type of hypersensitive reaction. The pathogenetic mechanisms underlying the allergy are unclear, although t...

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Material Type: 博士論文
ISSN: 2077-0383
Title: Metal Allergy Mediates the Development of Oral Lichen Planus via TSLP-TSLPR Signaling
Volume: 11 3
Author/Editor: Yunizar, Mohammad Fadyl
Watanabe, Megumi
Liu, Lipei
Minami, Norikazu
Ichikawa, Tetsuo
Author Heading: Yunizar, Mohammad Fadyl
Watanabe, Megumi
Liu, Lipei
Minami, Norikazu
Ichikawa, Tetsuo
Publication, Distribution, etc.: MDPI
Publication Date: 2022-01-20
Publication Date (W3CDTF): 2022-01-20
Alternative Title: 金属アレルギーはTSLP-TSLPRシグナルを介して口腔扁平苔癬の発症に関与する
Periodical title: Journal of Clinical Medicine
Degree grantor/type: 徳島大学
Date Granted: 2022-03-23
Date Granted (W3CDTF): 2022-03-23
Dissertation Number: 甲第3613号
Degree Type: 博士（歯学）
Conferring No. (Dissertation): 甲第3613号
Text Language Code: eng
Subject Heading: metal allergy
oral lichen planus
TSLP-TSLPR
Target Audience: 一般
Note (General): Metal allergy is a T-cell-mediated delayed type of hypersensitive reaction. The pathogenetic mechanisms underlying the allergy are unclear, although the condition has been reported to be related to oral lichen planus (OLP), despite an absence of immunological studies to support this relationship. In this study, histopathological samples of OLP patients were examined to compare the metal allergy-positive and -negative groups, with a focus on the network of epidermal keratinocytes and T cells induced by thymic stromal lymphopoietin (TSLP) and its receptor, TSLPR. Infiltration of T cells into the epithelium was revealed to be higher in the OLP lesions of metal allergy-positive patients than in those of metal allergy-negative patients. Moreover, TSLP-TSLPR signaling and TNF-α production were higher in the epithelial tissue samples of the metal allergy-positive patients than in the metal allergy-negative patients. Metal allergy is associated with both increased expressions of TSLP in keratinocytes and increased TNF-α levels in the epithelium. We propose that this would promote the accumulation of T cells at the lesion site, contributing to the formation of the disease. These results suggest that metal allergy may be an aggravating factor in the pathogenesis of OLP.
DOI: info:doi/10.3390/jcm11030519
https://doi.org/info:doi/10.3390/jcm11030519
Persistent ID (NDL): info:ndljp/pid/12296361
https://dl.ndl.go.jp/pid/12296361
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-06-05T18:01:14+09:00
Format (IMT): PDF
Access Restrictions: 国立国会図書館内限定公開
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Availability of remote photoduplication service: 可
Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/117036
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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