Bihormonal dysregulation of insulin and glucagon contributes to glucose intolerance development at one year post-delivery in women with gestational diabetes: a prospective cohort study using an early postpartum 75-g glucose tolerance test 68 8

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Bihormonal dysregulation of insulin and glucagon contributes to glucose intolerance development at one year post-delivery in women with gestational diabetes: a prospective cohort study using an early postpartum 75-g glucose tolerance test 8

Persistent ID (NDL): info:ndljp/pid/12296387

Material type: 博士論文

Author: 重野, 里代子

Publisher: The Japan Endocrine Society

Publication date: 2022-03-18

Material Format: Digital

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Name of awarding university/degree: Nagasaki University (長崎大学),博士(医学)

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Note (General)：: Gestational diabetes mellitus (GDM) is known to be a significant risk factor for the future development of type 2 diabetes. Here, we investigated whet...

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Material Type: 博士論文
ISSN: 0918-8959
Title: Bihormonal dysregulation of insulin and glucagon contributes to glucose intolerance development at one year post-delivery in women with gestational diabetes: a prospective cohort study using an early postpartum 75-g glucose tolerance test
Volume: 68 8
Author/Editor: 重野, 里代子
Author Heading: 重野, 里代子
Publication, Distribution, etc.: The Japan Endocrine Society
Publication Date: 2022-03-18
Publication Date (W3CDTF): 2022-03-18
Alternative Title: 妊娠糖尿病女性における産後１年後の耐糖能異常発症には、インスリンおよびグルカゴンの分泌障害が関与する（産褥期の75gOGTT検査を使用した前向きコホート研究）
Periodical title: Endocrine Journal
Degree grantor/type: Nagasaki University (長崎大学)
Date Granted: 2022-03-18
Date Granted (W3CDTF): 2022-03-18
Dissertation Number: 甲共医歯薬第20号
Degree Type: 博士(医学)
Conferring No. (Dissertation): 甲共医歯薬第20号
Text Language Code: eng
Subject Heading: Gestational diabetes
Glucagon
Insulin
Insulinogenic index
Hyperglucagonemia
Target Audience: 一般
Note (General): Gestational diabetes mellitus (GDM) is known to be a significant risk factor for the future development of type 2 diabetes. Here, we investigated whether a precise evaluation of β- and α-cell functions helps to identify women at high risk of developing glucose intolerance after GDM. Fifty-six women with GDM underwent a 75-g oral glucose tolerance test (OGTT) at early (6–12 weeks) postpartum. We measured their concentrations of glucose, insulin, proinsulin and glucagon at fasting and 30, 60 and 120 min. At 1-year post-delivery, we classified the women into a normal glucose tolerance (NGT) group or an impaired glucose tolerance (IGT)/diabetes mellitus (DM) group. Forty-three of the 56 women completed the study. At 1-year post-delivery, 17 women had developed IGT/DM and 26 women showed NGT. In the early-postpartum OGTTs, the IGT/DM group showed a lower insulinogenic index, a less glucagon suppression evaluated by the change from fasting to 30 min (ΔGlucagon 30 min), and a higher glucagon-to-insulin ratio at 30 min compared to the NGT group. There were no significant between-group differences in proinsulin levels or proinsulin-to-insulin ratios. Insulinogenic index <0.6 and ΔGlucagon 30 min >0 pg/mL were identified as predictors for the development of IGT/DM after GDM, independent of age, body mass index, and lactation intensity. These results suggest that the bihormonal disorder of insulin and glucagon causes the postpartum development of glucose intolerance. The measurement of plasma insulin and glucagon during the initial OGTT at early postpartum period can help to make optimal decisions regarding the postpartum management of women with GDM.
長崎大学学位論文学位記番号:共博(医歯薬)甲第20号学位授与年月日:令和4年3月18日
Author: Riyoko Shigeno, Ichiro Horie, Masaki Miwa, Ayako Ito, Ai Haraguchi, Shoko Natsuda, Satoru Akazawa, Ai Nagata, Yuri Hasegawa, Shoko Miura, Kiyonori Miura, Atsushi Kawakami, Norio Abiru
Citation: Endocrine Journal, 68(8), pp. 919-931; 2021
identifier:Nagasaki University (長崎大学), 博士(医学) (2022-03-18)
http://hdl.handle.net/10069/00041164
DOI: info:doi/10.1507/endocrj.EJ20-0795
https://doi.org/info:doi/10.1507/endocrj.EJ20-0795
Persistent ID (NDL): info:ndljp/pid/12296387
https://dl.ndl.go.jp/pid/12296387
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-06-05T18:01:14+09:00
Date Created (W3CDTF): 2022-05-30
Format (IMT): PDF
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Related Material (URI): http://hdl.handle.net/10069/00041164
Periodical Title (URI): http://hdl.handle.net/10069/00041572
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp