Endosialin/CD248 may be a potential therapeutic target to prevent the invasion and metastasis in osteosarcoma.

• Material Type: 博士論文
• ISSN: 1792-1074
• Title: Endosialin/CD248 may be a potential therapeutic target to prevent the invasion and metastasis in osteosarcoma.
• Volume: 23 2
• Author/Editor: Kondo, Yumiko; Honoki, Kanya; Kishi, Shingo; Mori, Shiori; Fujiwara-Tani, Rina; Tsukamoto, Shinji; Fujii, Hiromasa; Kuniyasu, Hiroki; Tanaka, Yasuhito
• Author Heading: Kondo, Yumiko; Honoki, Kanya; Kishi, Shingo; Mori, Shiori; Fujiwara-Tani, Rina; Tsukamoto, Shinji; Fujii, Hiromasa; Kuniyasu, Hiroki; Tanaka, Yasuhito
• Publication, Distribution, etc.: Spandidos Publications
• Publication Date: 2022-02; 23 2
• Publication Date (W3CDTF): 2022-02
• Alternative Title: エンドシアリン/CD248は骨肉腫の浸潤と転移を抑制する潜在的な治療標的となる可能性がある
• Periodical title: Oncology letters
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2022-03-15
• Date Granted (W3CDTF): 2022-03-15
• Dissertation Number: 甲第829号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第829号
• Text Language Code: eng
• Subject Heading: osteosarcoma; endosialin; invasion; metastasis
• Target Audience: 一般
• Note (General): type:Thesis; Endosialin/CD248/tumor endothelial marker 1 is classified as a C-type lectin-like transmembrane receptor, found on the plasma membrane of activated mesenchymal cells, which binds to fibronectin. Although endosialin is expressed at high levels in stem-like cells of sarcomas, its role has not been fully uncovered. The present study aimed to determine whether endosialin expression is associated with tumor progression and metastasis, and whether endosialin has the potential to act as a novel therapeutic target in osteosarcoma (OS) using MORAb-004/ontuxizumab, a humanized monoclonal antibody, which targets the type C lectin domain of endosialin. The results demonstrated that endosialin was highly expressed in OSs with metastatic disease. Furthermore, MORAb-004 had no cytostatic effect on OS cells in vitro and did not change the expression of stem cells and differentiation markers; however, it inhibited migration of OS cells. Taken together, these results suggest that endosialin may play a role in migration, and may be involved in the metastatic process of OSs. Furthermore, MORAb-004 reduces the motility of OS cells, and suppresses invasion and the development of metastatic lesions.; 博士（医学）・甲第829号・令和4年3月15日; Copyright: © Kondo et al. This is an open access article distributed under the terms of Creative Commons Attribution License(https://creativecommons.org/licenses/by-nc-nd/4.0/).; identifier:Oncology letters Vol.23 No.2 Article No.42 (2022 Feb); identifier:17921074; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/4012; identifier:Oncology letters, 23(2): Article No.42
• DOI: info:doi/10.3892/ol.2021.13160; https://doi.org/info:doi/10.3892/ol.2021.13160
• Persistent ID (NDL): info:ndljp/pid/12296422; https://dl.ndl.go.jp/pid/12296422
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2022-06-05T18:01:14+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10564/4012
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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