Fractal dimension in CT low attenuation areas is predictive of long-term oxygen therapy initiation in COPD patients: Results from two observational cohort studies.

• Material Type: 博士論文
• ISSN: 2212-5345
• Title: Fractal dimension in CT low attenuation areas is predictive of long-term oxygen therapy initiation in COPD patients: Results from two observational cohort studies.
• Volume: 60 1
• Author/Editor: Ibaraki, Takahiro; Tomoda, Koich; Fujioka, Nobuhiro; Sakaguchi, Kazuhiro; Fujita, Yukio; Yamamoto, Yoshifumi; Hontsu, Shigeto; Yamauchi, Motoo; Yoshikawa, Masanori; Tanabe, Naoya; Tanimura, Kazuya; Sato, Susumu; Saeki, Keigo; Muro, Shigeo
• Author Heading: Ibaraki, Takahiro; Tomoda, Koich; Fujioka, Nobuhiro; Sakaguchi, Kazuhiro; Fujita, Yukio; Yamamoto, Yoshifumi; Hontsu, Shigeto; Yamauchi, Motoo; Yoshikawa, Masanori; Tanabe, Naoya; Tanimura, Kazuya; Sato, Susumu; Saeki, Keigo; Muro, Shigeo
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2022-01; 60 1
• Publication Date (W3CDTF): 2022-01
• Alternative Title: CTにおける低吸収領域のフラクタル次元は、COPD患者の長期酸素療法開始を予測する : 2つのコホート研究結果より
• Periodical title: Respiratory investigation
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2022-03-15
• Date Granted (W3CDTF): 2022-03-15
• Dissertation Number: 甲第824号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第824号
• Text Language Code: eng
• Subject Heading: COPD; Computed tomography; Fractal property; Long term oxygen therapy (LTOT); Pulmonary function test
• Target Audience: 一般
• Note (General): type:Thesis; Background: Some chronic obstructive pulmonary disease (COPD) patients develop hypoxemia with disease progression, with some even requiring long-term oxygen therapy (LTOT). Lung function, especially diffusing capacity, and the annual decline in PaO₂, are reported to be predictive factors of chronic respiratory failure. However, the association between lung morphometry evaluated using computed tomography (CT) images and LTOT initiation is unknown. Methods: We retrospectively evaluated the relationship between clinical indices, including pulmonary function, body mass index (BMI), and CT parameters, at baseline and LTOT initiation in two prospective COPD cohorts. In the Nara Medical University cohort (n = 76), the low attenuation area (LAA) and its fractal dimension (fractal D) were adapted as the indices for parenchymal destruction in CT images. The association between these CT measurements and LTOT initiation was replicated in the Kyoto University cohort (n = 130). Results: In the Nara Medical University cohort, lower BMI (hazard ratio [HR]:0.70, p = 0.006), lower % diffusing capacity (%DLCO) (HR: 0.92, p = 0.006), lower %DLCO/VA (HR, 0.90, p = 0.008), higher RV/TLC (HR, 1.26, p = 0.012), higher LAA% (HR: 1.18, p = 0.001), and lower fractal D (HR: 3.27 × 10⁻⁸, p < 0.001) were associated with LTOT initiation. Multivariate analysis in the Kyoto University cohort confirmed that lower %DLCO and lower fractal D were independently associated with LTOT initiation, whereas LAA% was not. Conclusion: Fractal D, which is the index for morphometric complexity of LAA in CT analysis, is predictive of LTOT initiation in COPD patients.; 博士（医学）・甲第824号・令和4年3月15日; © 2021 The Authors Published by Elsevier B.V. on behalf of The Japanese Respiratory Society.; identifier:Respiratory investigation Vol.60 No.1 p.137-145 (2022 Jan); identifier:22125345; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/4007; identifier:Respiratory investigation, 60(1): 137-145
• DOI: info:doi/10.1016/j.resinv.2021.09.001; https://doi.org/info:doi/10.1016/j.resinv.2021.09.001
• Persistent ID (NDL): info:ndljp/pid/12296427; https://dl.ndl.go.jp/pid/12296427
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2022-06-05T18:01:14+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10564/4007
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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