Quantitative parameter mapping of contrast agent concentration and relaxivity and brain tumor extracellular pH 12

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Quantitative parameter mapping of contrast agent concentration and relaxivity and brain tumor extracellular pH

Persistent ID (NDL): info:ndljp/pid/12296659

Material type: 博士論文

Author: Matsumoto, Yukiほか

Publisher: Springer Nature

Publication date: 2022-02-09

Material Format: Digital

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Name of awarding university/degree: 徳島大学,博士（医学）

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Note (General)：: In clinical magnetic resonance imaging, gadolinium-based contrast agents are commonly used for detecting brain tumors and evaluating the extent of mal...

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Material Type: 博士論文
ISSN: 2045-2322
Title: Quantitative parameter mapping of contrast agent concentration and relaxivity and brain tumor extracellular pH
Volume: 12
Author/Editor: Matsumoto, Yuki
Harada, Masafumi
Kanazawa, Yuki
Taniguchi, Yo
Ono, Masaharu
Bito, Yoshitaka
Author Heading: Matsumoto, Yuki
Harada, Masafumi
Kanazawa, Yuki
Taniguchi, Yo
Ono, Masaharu
Bito, Yoshitaka
Publication, Distribution, etc.: Springer Nature
Publication Date: 2022-02-09
Publication Date (W3CDTF): 2022-02-09
Alternative Title: 造影剤濃度と緩和能の定量的パラメータマッピングと脳腫瘍細胞外pH
Periodical title: Scientific Reports
Degree grantor/type: 徳島大学
Date Granted: 2022-03-23
Date Granted (W3CDTF): 2022-03-23
Dissertation Number: 甲第3599号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第3599号
Text Language Code: eng
Subject Heading: MRI
QPM
pHe
pH
細胞外pH
Target Audience: 一般
Note (General): In clinical magnetic resonance imaging, gadolinium-based contrast agents are commonly used for detecting brain tumors and evaluating the extent of malignancy. We present a new method to evaluate relaxivity (r1) and contrast agent concentration separately in contrast-enhanced lesions using quantitative parameter mapping (QPM). Furthermore, we also aimed to estimate the extracellular pH (pHe) of tumor lesions. We demonstrated that it is possible to evaluate pathophysiological tumor changes due to therapeutic efficacy by measuring r1 in contrast-enhanced lesions. In this study, the primary brain tumor group showed significantly higher r1 values than other brain disease groups (P < 0.001). Moreover, mean pHe value showed a trend for tumor malignancy having a lower pHe value and primary brain tumor having a significantly lower pHe than other brain diseases (P < 0.001). Our results might suggest that QPM can separately quantify r1 and CA concentration in brain tumors and that pHe brain tumor mapping could serve as a tumor biomarker. In conclusion, our method has potential clinical applications for assessing the treatment effects.
DOI: info:doi/10.1038/s41598-022-05711-z
https://doi.org/info:doi/10.1038/s41598-022-05711-z
Persistent ID (NDL): info:ndljp/pid/12296659
https://dl.ndl.go.jp/pid/12296659
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-06-05T18:01:14+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/116994
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp