Effects of Betahistine on the Development of Vestibular Compensation after Unilateral Labyrinthectomy in Rats

• Material Type: 博士論文
• ISSN: 2076-3425
• Title: Effects of Betahistine on the Development of Vestibular Compensation after Unilateral Labyrinthectomy in Rats
• Volume: 11 3
• Author/Editor: Fukuda, Junya; Matsuda, Kazunori; Satou, Go; Kitahara, Tadashi; Matsuoka, Momoyo; Azuma, Takahiro; Kitamura, Yoshiaki; Tomita, Koichi; Takeda, Noriaki
• Author Heading: Fukuda, Junya; Matsuda, Kazunori; Satou, Go; Kitahara, Tadashi; Matsuoka, Momoyo; Azuma, Takahiro; Kitamura, Yoshiaki; Tomita, Koichi; Takeda, Noriaki
• Publication, Distribution, etc.: MDPI
• Publication Date: 2021-03-11
• Publication Date (W3CDTF): 2021-03-11
• Alternative Title: ベタヒスチンが一側内耳破壊後のラットの前庭代償に与える影響
• Periodical title: Brain Sciences
• Degree grantor/type: 徳島大学
• Date Granted: 2022-03-23
• Date Granted (W3CDTF): 2022-03-23
• Dissertation Number: 甲第3591号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第3591号
• Text Language Code: eng
• Subject Heading: vestibular compensation; betahistine dihydrochloride; medial vestibular nucleus; Fos; histamine H3 receptor
• Target Audience: 一般
• Note (General): Background: Vestibular compensation (VC) after unilateral labyrinthectomy (UL) consists of the initial and late processes. These processes can be evaluated based on the decline in the frequency of spontaneous nystagmus (SN) and the number of MK801-induced Fos-positive neurons in the contralateral medial vestibular nucleus (contra-MVe) in rats. Histamine H3 receptors (H3R) are reported to be involved in the development of VC. Objective: We examined the effects of betahistine, an H3R antagonist, on the initial and late processes of VC in UL rats. Methods: Betahistine dihydrochloride was continuously administered to the UL rats at doses of 100 and 200 mg/kg/day using an osmotic minipump. MK801 (1.0 mg/kg) was intraperitoneally administered on days 7, 10, 12, and 14 after UL, while Fos-positive neurons were immunohistochemically stained in the contra-MVe. Results: The SN disappeared after 42 h, and continuous infusion of betahistine did not change the decline in the frequency of SN. The number of MK801-induced Fos-positive neurons in contra-MVe significantly decreased on days 7, 10, and 12 after UL in a dose-dependent manner in the betahistine-treated rats, more so than in the saline-treated rats. Conclusion: These findings suggest that betahistine facilitated the late, but not the initial, process of VC in UL rats.
• DOI: info:doi/10.3390/brainsci11030360; https://doi.org/info:doi/10.3390/brainsci11030360
• Persistent ID (NDL): info:ndljp/pid/12296664; https://dl.ndl.go.jp/pid/12296664
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2022-06-05T18:01:14+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/116888
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp