Anti-Stem Cell Property of Pterostilbene in Gastrointestinal Cancer Cells.

• Material Type: 博士論文
• ISSN: 1422-0067
• Title: Anti-Stem Cell Property of Pterostilbene in Gastrointestinal Cancer Cells.
• Volume: 21 24
• Author/Editor: Mori, Shiori; Kishi, Shingo; Honoki, Kanya; Fujiwara-Tani, Rina; Moriguchi, Takuma; Sasaki, Takamitsu; Fujii, Kiyomu; Tsukamoto, Shinji; Fujii, Hiromasa; Kido, Akira; Tanaka, Yasuhito; Luo, Yi; Kuniyasu, Hiroki
• Author Heading: Mori, Shiori; Kishi, Shingo; Honoki, Kanya; Fujiwara-Tani, Rina; Moriguchi, Takuma; Sasaki, Takamitsu; Fujii, Kiyomu; Tsukamoto, Shinji; Fujii, Hiromasa; Kido, Akira; Tanaka, Yasuhito; Luo, Yi; Kuniyasu, Hiroki
• Publication, Distribution, etc.: MDPI
• Publication Date: 2020-12-08; 21 24
• Publication Date (W3CDTF): 2020-12-08
• Alternative Title: 消化器がん細胞におけるpterostilbeneの抗幹細胞作用
• Periodical title: International journal of molecular sciences
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2022-03-15
• Date Granted (W3CDTF): 2022-03-15
• Dissertation Number: 甲第821号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第821号
• Text Language Code: eng
• Subject Heading: pterostilbene; cancer; stemness; oxidative stress
• Target Audience: 一般
• Note (General): type:Thesis; Pterostilbene (PTE) is a natural sterbenoid contained in blueberries that has an antioxidant effect. In contrast, PTE also generates oxidative stress in cancer cells and provides an antitumor effect. Here, we examined the potential mechanism of this contrasting effect of PTE using three gastrointestinal cancer cell lines, namely CT26, HT29, and MKN74. PTE showed a dose-dependent inhibition of cell proliferation, sphere-forming ability, and stem cell marker expression in all three cell lines. Furthermore, the cells treated with PTE showed an increase in mitochondrial membrane potential and an increase in mitochondrial oxidative stress and lipid peroxide. Upon concurrent treatment with vitamin E, N-acetyl-L-cysteine, and PTE, the PTE-induced mitochondrial oxidative stress and growth inhibition were suppressed. These findings indicate that PTE induces oxidative stress in cancer cells, suppresses stemness, and inhibits proliferation. These antitumor effects of PTE are considered to be useful in cancer treatment.; 博士（医学）・甲第821号・令和4年3月15日; © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).; identifier:International journal of molecular sciences Vol.21 No.24 Article No.9347 (2020 Dec); identifier:14220067; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/4004; identifier:International journal of molecular sciences, 21(24): Article No.9347
• DOI: info:doi/10.3390/ijms21249347; https://doi.org/info:doi/10.3390/ijms21249347
• Persistent ID (NDL): info:ndljp/pid/12296696; https://dl.ndl.go.jp/pid/12296696
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2022-06-05T18:01:14+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10564/4004
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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