Neurotransmission through dopamine D1 receptors is required for aversive memory formation and Arc activation in the cerebral cortex

Persistent ID (NDL): info:ndljp/pid/12296849

Material type: 博士論文

Author: Saito, Nae

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Publication date: 2021-09-21

Material Format: Digital

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Name of awarding university/degree: 新潟大学,博士（医学）

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Note (General)：: Dopaminergic neurotransmission is considered to play an important role not only in reward-based learning, but also in aversive learning. Here, we inve...

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Material Type: 博士論文
Title: Neurotransmission through dopamine D1 receptors is required for aversive memory formation and Arc activation in the cerebral cortex
Author/Editor: Saito, Nae
Author Heading: Saito, Nae
Publication Date: 2021-09-21
Publication Date (W3CDTF): 2021-09-21
Alternative Title: ドーパミンD1受容体を介した神経伝達は、嫌悪記憶形成と大脳皮質におけるArc活性化に必要である。
Degree grantor/type: 新潟大学
Date Granted: 2021-09-21
Date Granted (W3CDTF): 2021-09-21
Dissertation Number: 甲第4931号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第4931号
Text Language Code: eng
Alias of Author: 齊藤, 奈英
Subject Heading: Dopamine D1 receptor
Aversive memory
Arc
Arg3.1
Venus
Three-dimensional imaging
Target Audience: 一般
Note (General): Dopaminergic neurotransmission is considered to play an important role not only in reward-based learning, but also in aversive learning. Here, we investigated the role of dopaminergic neurotransmission via dopamine D1 receptors (D1Rs) in aversive memory formation in a passive avoidance test using D1R knockdown (KD) mice, in which the expression of D1Rs can conditionally and reversibly be controlled by doxycycline (Dox) treatment. We also performed whole-brain imaging after aversive footshock stimulation in activity-regulated cytoskeleton protein (Arc)-dVenus D1RKD mice, which were crossbred from Arc-dVenus transgenic mice and D1RKD mice, to examine the distribution of Arc-controlled dVenus expression in the hippocampus and cerebral cortex during aversive memory formation. Knockdown of D1R expression following Dox treatment resulted in impaired performance in the passive avoidance test and was associated with a decrease in dVenus expression in the cerebral cortex (visual, somatosensory, and motor cortices), but not the hippocampus, compared with control mice without Dox treatment. These findings indicate that D1R-mediated dopaminergic transmission is critical for aversive memory formation, specifically by influencing Arc expression in the cerebral cortex.
Neuroscience research. 2020, 156, 58-65.
新大院博(医)第1021号
Persistent ID (NDL): info:ndljp/pid/12296849
https://dl.ndl.go.jp/pid/12296849
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-06-05T18:01:14+09:00
Format (IMT): application/pdf
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Availability of remote photoduplication service: 可
Periodical Title (URI): http://hdl.handle.net/10191/0002000463
https://niigata-u.repo.nii.ac.jp/records/2000463
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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