Sustained Stimulation by Low-dose Lipopolysaccharide Prolongs Trabecular Structure Deterioration and Immaturity of Collagen at Regenerated Bone Even After Bone Volume Recovery

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Sustained Stimulation by Low-dose Lipopolysaccharide Prolongs Trabecular Structure Deterioration and Immaturity of Collagen at Regenerated Bone Even After Bone Volume Recovery

Persistent ID (NDL): info:ndljp/pid/12296864

Material type: 博士論文

Author: 久留島, 悠司

Publisher: -

Publication date: 2022-03-04

Material Format: Digital

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Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: Despite rapid advances in the field of bone regeneration therapy, little is known about information related to the quality of bone regenerated under c...

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Material Type: 博士論文
Title: Sustained Stimulation by Low-dose Lipopolysaccharide Prolongs Trabecular Structure Deterioration and Immaturity of Collagen at Regenerated Bone Even After Bone Volume Recovery
Author/Editor: 久留島, 悠司
Author Heading: 久留島, 悠司
Publication Date: 2022-03-04
Publication Date (W3CDTF): 2022-03-04
Alternative Title: 低用量のリポポリサッカライドによる持続的な刺激は骨量が回復しても再生骨の骨梁構造の劣化およびコラーゲンの未成熟を長引かせる
Degree grantor/type: 大阪歯科大学
Date Granted: 2022-03-04
Date Granted (W3CDTF): 2022-03-04
Dissertation Number: 甲第933号
Degree Type: 博士（歯学）
Conferring No. (Dissertation): 甲第933号
Text Language Code: eng
Subject Heading: Bone quality
collagen
micro-CT
picrosirius red staining
Target Audience: 一般
Note (General): Despite rapid advances in the field of bone regeneration therapy, little is known about information related to the quality of bone regenerated under chronic inflammation. This study was carried out to compare the qualities (trabecular structure and collagen maturity) of regenerated bone in rat calvaria defects under different conditions of lipopolysaccharide (LPS) stimulation. To generate different residual levels of LPS at the defect sites, two types of gelatin sponges that release the bacterial endotoxin at different rates were applied; namely, LPS sustained-release gelatin (LS-G) sponge and LPS rapid-release gelatin (LR-G) sponge. Histomorphometric analysis by micro-computed tomography showed that, compared with rapid LPS stimulation with the LR-G sponge, sustained low-dose LPS stimulation using the LS-G sponge markedly impaired bone regeneration for up to 3 weeks, but not at 6 weeks, and induced a vulnerable trabecular structure. Polarized light microscopy with picrosirius red-stained tissue samples revealed that the LS-G sponge generated immature collagen in the regenerated bone. These deleterious changes in the trabecular structure and in collagen maturation were retained even after recovery of the bone volume at 6 weeks. These findings provide insights into the quality of regenerated bone during and after chronic inflammation.
2021年度
Persistent ID (NDL): info:ndljp/pid/12296864
https://dl.ndl.go.jp/pid/12296864
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-06-05T18:01:14+09:00
Date Created (W3CDTF): 2022-05-13
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://id.nii.ac.jp/1392/00000310/
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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