Tailoring Silicon Nitride Surface Chemistry for Facilitating Odontogenic Differentiation of Rat Dental Pulp Cells

• Material Type: 博士論文
• Title: Tailoring Silicon Nitride Surface Chemistry for Facilitating Odontogenic Differentiation of Rat Dental Pulp Cells
• Author/Editor: 鞏, 雅楠
• Author Heading: 鞏, 雅楠
• Publication Date: 2022-03-04
• Publication Date (W3CDTF): 2022-03-04
• Alternative Title: ラット歯髄細胞の象牙芽細胞分化を促進するための窒化ケイ素表面化学の調製
• Degree grantor/type: 大阪歯科大学
• Date Granted: 2022-03-04
• Date Granted (W3CDTF): 2022-03-04
• Dissertation Number: 甲第932号
• Degree Type: 博士（歯学）
• Conferring No. (Dissertation): 甲第932号
• Text Language Code: eng
• Subject Heading: dental pulp cells｜odontogenic differentiation｜silicon nitride｜surface wettability｜cell adhesion
• Target Audience: 一般
• Note (General): Silicon nitride (Si3N4) can facilitate bone formation; hence, it is used as a biomaterial in orthopedics. Nevertheless, its usability for dentistry is unexplored. The aim of the present study was to investigate the effect of Si3N4 granules for the proliferation and odontogenic differentiation of ratdental pulp cells (rDPCs). Four different types of Si3N4 granules were prepared, which underwent different treatments to form pristine as-synthesized Si3N4, chemically treated Si3N4, thermally treated Si3N4, and Si3N4 sintered with 3 wt.% yttrium oxide (Y2O3). rDPCs were cultured on or around the Si3N4 granular beds. Compared with the other three types of Si3N4 granules, the sintered Si3N4 granules significantly promoted cellular attachment, upregulated the expression of odontogenic marker genes (Dentin Matrix Acidic Phosphoprotein 1 and Dentin Sialophosphoprotein) in the early phase, and enhanced the formation of mineralization nodules. Furthermore, the water contact angle of sintered Si3N4 was also greatly increased to 40o . These results suggest that the sintering process forSi3N4 with Y2O3 positively altered the surface properties of pristine as-synthesized Si3N4 granules, thereby facilitating the odontogenic differentiation of rDPCs. Thus, the introduction of a sintering treatment for Si3N4 granules is likely to facilitate their use in the clinical application of dentistry.; 2021年度
• Persistent ID (NDL): info:ndljp/pid/12296865; https://dl.ndl.go.jp/pid/12296865
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2022-06-05T18:01:14+09:00
• Date Created (W3CDTF): 2022-05-13
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://id.nii.ac.jp/1392/00000309/
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

Table of Contents

2023-09-07 再収集