The Role of Syndecans in the Human Dental Pulp

Persistent ID (NDL): info:ndljp/pid/12296880

Material type: 博士論文

Author: 津田, 賢治

Publisher: -

Publication date: 2022-03-04

Material Format: Digital

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Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: Objectives: Syndecans (SDCs) are a family of cell surface heparan sulfate proteoglycans known to play critical roles in regulating multiple cellular...

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Material Type: 博士論文
Title: The Role of Syndecans in the Human Dental Pulp
Author/Editor: 津田, 賢治
Author Heading: 津田, 賢治
Publication Date: 2022-03-04
Publication Date (W3CDTF): 2022-03-04
Alternative Title: ヒト歯髄におけるシンデカンの役割
Degree grantor/type: 大阪歯科大学
Date Granted: 2022-03-04
Date Granted (W3CDTF): 2022-03-04
Dissertation Number: 甲第916号
Degree Type: 博士（歯学）
Conferring No. (Dissertation): 甲第916号
Text Language Code: eng
Subject Heading: dental pulp cells
inflammation
syndecans
Target Audience: 一般
Note (General): Objectives: Syndecans (SDCs) are a family of cell surface heparan sulfate proteoglycans known to play critical roles in regulating multiple cellular functions, including participation in inflammation and wound healing as a host defense mole-cule. The present study was undertaken to analyze the role of syndecan family in human dental pulp cells and the effect of an inflammatory cytokine. Materials and methods: Human dental pulp cell cultures from impacted third molars were established. Cells were cultured with the inflammatory mediator in-terleukin-1beta (IL-1beta). The gene expressions of SDCs were analysed by quan-titative RT-PCR. Results and significance: The relative level of mRNA expressions for SDC1 and SDC2 increased with cell proliferation, but both of them were suppressed signifi-cantly by IL-1beta stimulation. The expression of SDC3 remained unaltered by IL-1beta, although the expression level for SDC4 showed a rapid and strong increase. SDC4 was shed into the culture medium in a process involving MMPs. Shedding of SDC4 was increased after IL-1beta-stimulation. Our data demon-strate that all of SDC family express in human dental pulp cells and play different roles, and, most notably, SDC4 is involved in acute inflammation.
2021年度
Persistent ID (NDL): info:ndljp/pid/12296880
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Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
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Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-06-05T18:01:14+09:00
Date Created (W3CDTF): 2022-05-13
Format (IMT): application/pdf
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Periodical Title (URI): http://id.nii.ac.jp/1392/00000293/
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