Characteristics and serology of pregnant women with cytomegalovirus immunoglobulin G seroconversion during pregnancy in Japan

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Characteristics and serology of pregnant women with cytomegalovirus immunoglobulin G seroconversion during pregnancy in Japan

Persistent ID (NDL): info:ndljp/pid/12297038

Material type: 博士論文

Author: Shimada, Kyoko

Publisher: 三重大学

Publication date: 2021-12-15

Material Format: Digital

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Name of awarding university/degree: 三重大学,博士(医学)

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Note (General)：: application/pdfObjective: Investigate the characteristics and serology of pregnant women with cytomegalovirus (CMV) immunoglobulin (Ig)G seroconversio...

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Material Type: 博士論文
Title: Characteristics and serology of pregnant women with cytomegalovirus immunoglobulin G seroconversion during pregnancy in Japan
Author/Editor: Shimada, Kyoko
Author Heading: Shimada, Kyoko
Publication, Distribution, etc.: 三重大学
Publication Date: 2021-12-15
Publication Date (W3CDTF): 2021-12-15
Degree grantor/type: 三重大学
Date Granted: 2021-12-15
Date Granted (W3CDTF): 2021-12-15
Dissertation Number: 甲医学第2101号
Degree Type: 博士(医学)
Conferring No. (Dissertation): 甲医学第2101号
Text Language Code: eng
Alias of Author: シマダ, キョウコ
島田, 京子
濵﨑, 京子
Subject Heading: Congenital cytomegalovirus infection
Immunoglobulin G
Immunoglobulin M
Primary cytomegalovirus infection
Teenagers
Target Audience: 一般
Note (General): application/pdf
Objective: Investigate the characteristics and serology of pregnant women with cytomegalovirus (CMV) immunoglobulin (Ig)G seroconversion during pregnancy to understand the risk factors associated with primary CMV infection and the occurrence of fetal congenital CMV infection.Materials and methods: We retrospectively studied 3202 pregnant women who were CMV IgG-negative in early pregnancy and were retested for IgG in late pregnancy. Characteristics were compared between participants with and without IgG seroconversion, and serological parameters were compared between participants with and without fetal congenital CMV infection.Results: Twenty-six participants showed CMV IgG seroconversion and fifteen showed fetal congenital CMV infection. Seroconversion rates were significantly higher in teens (5.0%) than in older women (20s: 0.8%; 30s and over: 0.6%) (p < 0.001). Titers of CMV IgM at IgG seroconversion were higher in women without (median 8.66) than with (median 6.54) congenital infection (p=0.045). The congenital infection rate was high when IgM titers at IgG seroconversion were low (47.1% with 4.00-12.00 titers and 100% with 1.21-3.99 IgM titers) (p =0.048).Conclusions: Nulliparous pregnant teenagers have a high risk of CMV IgG seroconversion and the CMV IgM titer at IgG seroconversion may help predict the occurrence of fetal congenital CMV infection.
本文/Department of Obstetrics and Gynecology, Mie University Graduate School of Medicine, Tsu, Japan
7p
DOI: info:doi/10.1016/j.tjog.2021.05.008
https://doi.org/info:doi/10.1016/j.tjog.2021.05.008
Persistent ID (NDL): info:ndljp/pid/12297038
https://dl.ndl.go.jp/pid/12297038
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-06-05T18:01:14+09:00
Date Created (W3CDTF): 2022-05-09
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://hdl.handle.net/10076/00020318
https://mie-u.repo.nii.ac.jp/records/14700
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp