Donor-derived M2 macrophages attenuate GVHD after allogeneic hematopoietic stem cell transplantation

Persistent ID (NDL): info:ndljp/pid/12297039

Material type: 博士論文

Author: Hanaki, Ryo

Publisher: 三重大学

Publication date: 2021-12-15

Material Format: Digital

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Name of awarding university/degree: 三重大学,博士(医学)

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Note (General)：: application/pdfIntroduction: Graft-versus-host disease (GVHD) is frequent and fatal complication following allogeneic hematopoietic stem cell transpla...

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Material Type: 博士論文
Title: Donor-derived M2 macrophages attenuate GVHD after allogeneic hematopoietic stem cell transplantation
Author/Editor: Hanaki, Ryo
Author Heading: Hanaki, Ryo
Publication, Distribution, etc.: 三重大学
Publication Date: 2021-12-15
Publication Date (W3CDTF): 2021-12-15
Degree grantor/type: 三重大学
Date Granted: 2021-12-15
Date Granted (W3CDTF): 2021-12-15
Dissertation Number: 甲医学第2100号
Degree Type: 博士(医学)
Conferring No. (Dissertation): 甲医学第2100号
Text Language Code: eng
Alias of Author: ハナキ, リョウ
花木, 良
Subject Heading: graft-versus-host disease (GVHD)
hematopoietic stem cell transplantation (HSCT)
M1 macrophage
M2 macrophage
M-CSF
Target Audience: 一般
Note (General): application/pdf
Introduction: Graft-versus-host disease (GVHD) is frequent and fatal complication following allogeneic hematopoietic stem cell transplantation (HSCT) and characteristically involves skin, gut, and liver. Macrophages promote tissue regeneration and mediate immunomodulation. Macrophages are divided into two different phenotypes, classically activated M1 (pro-inflammatory or immunereactive macrophages) and alternatively activated M2 (anti-inflammatory or immune-suppressive macrophages). The anti-inflammatory effect of M2 macrophage led us to test its effect in the pathophysiology of GVHD.Methods: GVHD was induced in lethally irradiated BALB/c mice. M2 macrophages derived from donor bone marrow (BM) were administered intravenously, while controls received donor BM-mononuclear cells and splenocytes. Animals were monitored for clinical GVHD and analyzed.Results: We confirmed that administering donor BM-derived M2 macrophages attenuated GVHD severity and prolonged survival after HSCT. Moreover, donor BM-derived M2 macrophages significantly suppressed donor T cell proliferation by cell-to-cell contact in vitro.Conclusions: We showed the protective effects of donor-derived M2 macrophages on GVHD and improved survival in a model of HSCT. Our data suggest that donor-derived M2 macrophages offer the potential for cell-based therapy to treat GVHD.
本文/Department of Pediatrics, Mie University Graduate School of Medicine, Tsu, Mie, Japan
11p
DOI: info:doi/10.1002/iid3.503
https://doi.org/info:doi/10.1002/iid3.503
Persistent ID (NDL): info:ndljp/pid/12297039
https://dl.ndl.go.jp/pid/12297039
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-06-05T18:01:14+09:00
Date Created (W3CDTF): 2022-05-09
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://hdl.handle.net/10076/00020317
https://mie-u.repo.nii.ac.jp/records/14699
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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