Meal ingestion Ceraceomyces tessulatus (Agaricomycetes) protects against NASH in mice

Persistent ID (NDL): info:ndljp/pid/12297125

Material type: 博士論文

Author: Suzuki, Hiroshi

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Publication date: 2021-09-21

Material Format: Digital

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Name of awarding university/degree: 新潟大学,博士（医学）

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Note (General)：: Non-alcoholic steatohepatitis (NASH) is becoming the most common cause of hepatocellular carcinoma (HCC) in developed countries. Oxidative stress play...

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Material Type: 博士論文
Title: Meal ingestion Ceraceomyces tessulatus (Agaricomycetes) protects against NASH in mice
Author/Editor: Suzuki, Hiroshi
Author Heading: Suzuki, Hiroshi
Publication Date: 2021-09-21
Publication Date (W3CDTF): 2021-09-21
Alternative Title: 越後白雪茸のマウスでの食事摂取によるNASH進行抑制効果
Effect of Basidiomycetes-X in NASH mice
Degree grantor/type: 新潟大学
Date Granted: 2021-09-21
Date Granted (W3CDTF): 2021-09-21
Dissertation Number: 甲第4932号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第4932号
Text Language Code: eng
Alias of Author: 鈴木, 浩史
Subject Heading: Functional food
Lipogenesis
Non-alcoholic Fatty Liver Disease
Medicinal mushrooms and fungi
Target Audience: 一般
Note (General): Non-alcoholic steatohepatitis (NASH) is becoming the most common cause of hepatocellular carcinoma (HCC) in developed countries. Oxidative stress plays a major role in the pathogenesis of NASH due to steatosis and, hence, novel therapeutic approaches might include natural antioxidants. Ceraceomyces tessulatus (strain BDM-X), a novel edible mushroom, possesses potent antioxidant activity. This study aimed to investigate the hepatoprotective effect of BDM-X in a novel NASH-HCC mouse model. To prepare this animal model, 2-day-old C57BL/6J male pups were exposed to low-dose streptozotocin (STZ), and at 4 weeks of age they were randomly divided into 2 groups: the NASH group (NASH) received a high-fat diet (HFD32) up to 14 weeks of age; the BDM-X group (BDM-X) received HFD32 up to age 10 weeks, followed by HFD32 + 20% BDM-X (percentage W/W in the diet) up to age 14 weeks. Mice not treated with STZ fed a normal diet served as a control group. We found that BDM-X improved serum aminotransferase levels as well as histopathological features such as steatosis, inflammatory foci, and pericellular fibrosis in NASH mice. Hepatic protein expression of SREBP-1 and PPARα was significantly increased in NASH mice. BDM-X treatment normalized the expression of both proteins. Our data suggest the BDM-X may protect the liver against lipogenesis in NASH-HCC mice.
International journal of medicinal mushrooms. 2022, 24(1), 41-52.
新大院博(医)第1022号
Persistent ID (NDL): info:ndljp/pid/12297125
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Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-06-05T18:01:14+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
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Periodical Title (URI): http://hdl.handle.net/10191/0002000464
https://niigata-u.repo.nii.ac.jp/records/2000464
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