Small extracellular vesicles derived from interferon-γ pre-conditioned mesenchymal stromal cells effectively treat liver fibrosis

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Small extracellular vesicles derived from interferon-γ pre-conditioned mesenchymal stromal cells effectively treat liver fibrosis

Persistent ID (NDL): info:ndljp/pid/12297130

Material type: 博士論文

Author: Takaeuchi, Suguru

Publisher: -

Publication date: 2021-09-21

Material Format: Digital

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Name of awarding university/degree: 新潟大学,博士（医学）

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Note (General)：: Mesenchymal stromal cells (MSCs) are used for ameliorating liver fibrosis and aiding liver regeneration after cirrhosis; Here, we analyzed the therape...

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Material Type: 博士論文
Title: Small extracellular vesicles derived from interferon-γ pre-conditioned mesenchymal stromal cells effectively treat liver fibrosis
Author/Editor: Takaeuchi, Suguru
Author Heading: Takaeuchi, Suguru
Publication Date: 2021-09-21
Publication Date (W3CDTF): 2021-09-21
Alternative Title: インターフェロンγで刺激した間葉系幹細胞由来のエクソソームは肝線維化を効率的に改善する
Degree grantor/type: 新潟大学
Date Granted: 2021-09-21
Date Granted (W3CDTF): 2021-09-21
Dissertation Number: 甲第4926号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第4926号
Text Language Code: eng
Alias of Author: 竹内, 卓
Target Audience: 一般
Note (General): Mesenchymal stromal cells (MSCs) are used for ameliorating liver fibrosis and aiding liver regeneration after cirrhosis; Here, we analyzed the therapeutic potential of small extracellular vesicles (sEVs) derived from interferon-γ (IFN-γ) pre-conditioned MSCs (γ-sEVs). γ-sEVs effectively induced anti-inflammatory macrophages with high motility and phagocytic abilities in vitro, while not preventing hepatic stellate cell (HSC; the major source of collagen fiber) activation in vitro. The proteome analysis of MSC-derived sEVs revealed anti-inflammatory macrophage inducible proteins (e.g., annexin-A1, lactotransferrin, and aminopeptidase N) upon IFN-γ stimulation. Furthermore, by enabling CX_3CR1+ macrophage accumulation in the damaged area, γ-sEVs ameliorated inflammation and fibrosis in the cirrhosis mouse model more effectively than sEVs. Single cell RNA-Seq analysis revealed diverse effects, such as induction of anti-inflammatory macrophages and regulatory T cells, in the cirrhotic liver after γ-sEV administration. Overall, IFN-γ pre-conditioning altered sEVs resulted in efficient tissue repair indicating a new therapeutic strategy.
NPJ Regenerative medicine. 2021, 6(1), 19.
新大院博(医)第1016号
Persistent ID (NDL): info:ndljp/pid/12297130
https://dl.ndl.go.jp/pid/12297130
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-06-05T18:01:14+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://hdl.handle.net/10191/0002000458
https://niigata-u.repo.nii.ac.jp/records/2000458
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp