Effects of high-intensity red LED on hard tissue formation and expression of inflammatory cytokines in human bone marrow mesenchymal stem cells

Persistent ID (NDL): info:ndljp/pid/12297224

Material type: 博士論文

Author: 蔡, 祐維

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Publication date: 2021-09-22

Material Format: Digital

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Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: Photodynamic therapy using lisht emitting diodes (LEDs) and lasers has been shown effective for periodontal treatment. In previous research, we found ...

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Material Type: 博士論文
Title: Effects of high-intensity red LED on hard tissue formation and expression of inflammatory cytokines in human bone marrow mesenchymal stem cells
Author/Editor: 蔡, 祐維
Author Heading: 蔡, 祐維
Publication Date: 2021-09-22
Publication Date (W3CDTF): 2021-09-22
Alternative Title: ヒト骨髄間葉系幹細胞の硬組織形成と炎症性サイトカインの発現に対する高出力赤色LEDの影響
Degree grantor/type: 大阪歯科大学
Date Granted: 2021-09-22
Date Granted (W3CDTF): 2021-09-22
Dissertation Number: 乙第1636号
Degree Type: 博士（歯学）
Conferring No. (Dissertation): 乙第1636号
Text Language Code: eng
Subject Heading: LED
BMSC
Cytotoxicity
Target Audience: 一般
Note (General): Photodynamic therapy using lisht emitting diodes (LEDs) and lasers has been shown effective for periodontal treatment. In previous research, we found that high-intensity red LEDs promote hard tissue formation of human periodontal ligament stem cells and human bone marrow mesenchymal stem cells (BMSCs). On the other hands, it has been suggested that LED might induce cytotoxicity and inflammtion. Therefore, we investigated the biological effect of high-intensity red LEDs on BMSCs, including cytotoxicity and inflammation. A high-intensity red LED manufactured by Led Engin was used as a light source, and the irradiation energy was adjusted by changing the irradiation time. We performed cell proliferation and cytotoxicity assays, and examined the mineralization by alizarin red staining and the expression of IL-6 and IL-8. LED irradiation suppressed cell proliferation, and promoted cytotoxicity in an energy dose-dependent manner at 48 hours of irradiation. The mineralization tended to be promoted most at 6J/cm2. LED irradiation promoted the expression of IL-6 at 48 hours, and the expression of IL-8 at 24 and 48 hours. In conclusion, high-intensity red LED might promote the calcification of BMSCs, while promoting the cytotoxicity and gene expression of inflammatory cytokines.
2021年度
Persistent ID (NDL): info:ndljp/pid/12297224
https://dl.ndl.go.jp/pid/12297224
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-06-05T18:01:14+09:00
Date Created (W3CDTF): 2021-10-12
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://id.nii.ac.jp/1392/00000287/
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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