アルツハイマー病モデルマウスにおける認知機能、海馬Aβ沈着、神経細胞喪失、神経炎症、酸化ストレスに対する低強度運動バランス運動と協調運動の効果

• Material Type: 博士論文
• Title: アルツハイマー病モデルマウスにおける認知機能、海馬Aβ沈着、神経細胞喪失、神経炎症、酸化ストレスに対する低強度運動バランス運動と協調運動の効果
• Author/Editor: 中西, 和毅
• Author Heading: 中西, 和毅
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2021-03-25
• Publication Date (W3CDTF): 2021-03-25
• Alternative Title: Effects of low intensity motor balance and coordination exercise on cognitive functions, hippocampal Aβ deposition, neuronal loss, neuroinflammation, and oxidative stress in a mouse model of Alzheimer’s disease
• Degree grantor/type: 鹿児島大学
• Date Granted: 2021-03-25
• Date Granted (W3CDTF): 2021-03-25
• Dissertation Number: 甲保研第24号
• Degree Type: 博士（保健学）; Doctor of Philosophy in Health Science
• Conferring No. (Dissertation): 甲保研第24号
• Text Language Code: eng
• Subject Heading: SAMP8; Rotarod exercise; Neuroinflammation; M1 phenotype microglia; A1 phenotype astrocyte; Nitric oxide synthase activity
• NDC: 490
• Target Audience: 一般
• Note (General): 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨; It is well known that physical exercise reduces the risk of Alzheimer's disease (AD) and age-related cognitive decline. However, its mechanisms are still not fully understood. This study aimed to investigate the effect of aging and rotarod exercise (Ex) on cognitive function and AD pathogenesis in the hippocampus using senescence-accelerated mice prone 8 (SAMP8). Cognitive functions clearly declined at 9-months of age. Amyloid-beta (Aβ) deposition, neuronal loss, and glia activation-induced neuroinflammation increased with aging. The rotarod Ex prevented the decline of cognitive functions corresponding to the suppression of Aβ deposition, neuroinflammation, neuronal loss, inducible nitric oxide synthase (NOS) activities, and neuronal NOS activities. In addition, the rotarod Ex suppressed proinflammatory M1 phenotype microglia and A1 phenotype astrocytes. Our findings suggest that low-intensity motor balance and coordination exercise prevented age-related cognitive decline in the early stage of AD progression, possibly through the suppression of hippocampal Aβ deposition, neuronal loss, oxidative stress, and neuroinflammation, including reduced M1 and A1 phenotypes microglia and astrocytes.Kazuki Nakanishi, Harutoshi Sakakima, Kosuke Norimatsu, Shotaro Otsuka, Seiya Takada, Akira Tani, Kiyoshi KikuchiEffects of low intensity motor balance and coordination exercise on cognitive functions, hippocampal Aβ deposition, neuronal loss, neuroinflammation, and oxidative stress in a mouse model of Alzheimer’s diseaseExperimental Neurology 337, 2021 113590https://doi.org/10.1016/j.expneurol.2020.113590
• Persistent ID (NDL): info:ndljp/pid/12297361; https://dl.ndl.go.jp/pid/12297361
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2022-06-05T18:01:14+09:00
• Date Created (W3CDTF): 2021-03-25
• Format (IMT): PDF; application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10232/00031639
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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