A quantitative analysis of bone lamellarity and bone collagen linearity induced by distinct dosing and frequencies of teriparatide administration in ovariectomized rats and monkeys

• Material Type: 博士論文
• Title: A quantitative analysis of bone lamellarity and bone collagen linearity induced by distinct dosing and frequencies of teriparatide administration in ovariectomized rats and monkeys
• Author/Editor: 佐藤, 孝紀
• Author Heading: 佐藤, 孝紀
• Publication, Distribution, etc.: Hokkaido University
• Publication Date: 2022-03-24
• Publication Date (W3CDTF): 2022-03-24
• Alternative Title: 卵巣摘出ラットおよびサルにおけるテリパラチドの投与量および投与頻度の違いにより生じる、骨の層板構造および骨コラーゲンの直線性の変化の定量的解析
• Contributor: 飯村, 忠浩; 網塚, 憲生; 山本, 恒之
• Degree grantor/type: 北海道大学
• Date Granted: 2022-03-24
• Date Granted (W3CDTF): 2022-03-24
• Dissertation Number: 甲第15022号
• Degree Type: 博士(歯学)
• Conferring No. (Dissertation): 甲第15022号
• Text Language Code: eng
• Subject Heading: bone lamellarity; collagen linearity; multi-photon microscopy; SHG (second harmonic generation); semi-automatic recognition; teriparatide
• NDC: 497
• Target Audience: 一般
• Note (General): The lamellar structure of bone, which endows biomechanical rigidity to support the host organism, is observed in mammals, including humans. It is therefore essential to develop a quantitative analysis to evaluate the lamellarity of bone, which would especially be useful for the pharmacological evaluation of anti-osteoporotic drugs. This study applied a current system for the semi-automatic recognition of fluorescence signals to the analysis of un-decalcified bone sections from rat and monkey specimens treated with teriparatide (TPTD). Our analyses on bone formation pattern and collagen topology indicated that TPTD augmented bone lamellarity and bone collagen linearity, which were possibly associated with the recovery of collagen cross-linking, thus endowing bone rigidity.; (主査) 教授 飯村 忠浩, 教授 網塚 憲生, 教授 山本 恒之; 歯学院（口腔医学専攻）; Sato, Takanori et al. “A quantitative analysis of bone lamellarity and bone collagen linearity induced by distinct dosing and frequencies of teriparatide administration in ovariectomized rats and monkeys.” Microscopy (Oxford, England) vol. 70,6 (2021).
• DOI: 10.14943/doctoral.k15022; https://doi.org/10.14943/doctoral.k15022
• Persistent ID (NDL): info:ndljp/pid/12303023; https://dl.ndl.go.jp/pid/12303023
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2022-07-05T02:30:21+09:00
• Date Created (W3CDTF): 2022-03
• Format (IMT): PDF
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://dx.doi.org/10.14943/doctoral.k15022; http://hdl.handle.net/2115/86039
• Is Version Of (URI): https://doi.org/10.1093/jmicro/dfab020
• Is Referenced By (URI): http://hdl.handle.net/2115/86002
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

• Summary, etc.: The lamellar structure of bone, which endows biomechanical rigidity to support the host organism, is observed in mammals, including humans. It is ther...