Comparison of the wound-healing efficacy of gelatin sponge dressings and that of artificial dermis using atelocollagen in a rat cranial periosteal defect model.

Persistent ID (NDL): info:ndljp/pid/12304053

Material type: 博士論文

Author: 浅田, 泰幸ほか

Publisher: Japanese Association for Laboratory Animal Science

Publication date: 2022-05-20

Material Format: Digital

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Name of awarding university/degree: 滋賀医科大学,博士（医学）

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Note (General)：: pdfIn oral surgery, tissue loss may occur in some cases, resulting in bone exposure and subsequent wound infection and possible scar formation during ...

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Material Type: 博士論文
ISSN: 1881-7122
Title: Comparison of the wound-healing efficacy of gelatin sponge dressings and that of artificial dermis using atelocollagen in a rat cranial periosteal defect model.
Volume: 71 2
Author/Editor: 浅田, 泰幸
ASADA, Yasuyuki
Author Heading: 浅田, 泰幸
ASADA, Yasuyuki
Publication, Distribution, etc.: Japanese Association for Laboratory Animal Science
Publication Date: 2022-05-20
Publication Date (W3CDTF): 2022-05-20
Periodical title: Experimental animals
Degree grantor/type: 滋賀医科大学
Date Granted: 2022-03-10
Date Granted (W3CDTF): 2022-03-10
Dissertation Number: 乙第468号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 乙第468号
Text Language Code: eng
Subject Heading: artificial dermis
atelocollagen
cortactin
dressing material
wound healing
Target Audience: 一般
Note (General): pdf
In oral surgery, tissue loss may occur in some cases, resulting in bone exposure and subsequent wound infection and possible scar formation during secondary healing. In this study, Terudermis® Artificial Dermis (AD-T), a dermal defect graft made from processed bovine dermis collagen and gelatin sponge (GS) were used as dressings on 100-mm2 wounds with exposed bone on the heads of rats. For the control group, the wound was left exposed. The wound-healing efficacy of the treatment was compared macroscopically and histologically among the three groups at 1, 2, and 4 weeks after surgery. Complete wound healing was achieved faster in the AD-T group than in the GS group, and osteoblasts appeared on the bone surface, indicating accelerated bone remodeling. Furthermore, in the AD-T group, there was an increased production of newly formed blood vessels, fibroblasts and osteoblasts positive for anti-cortactin antibodies, which are believed to contribute to wound healing. Our findings suggest that AD-T is better than GS as a wound dressing material.
Thesis or Dissertation
令和3年度
10.1538/expanim.21-0049
博士論文要旨
DOI: info:doi/10.1538/expanim.21-0049
https://doi.org/info:doi/10.1538/expanim.21-0049
Persistent ID (NDL): info:ndljp/pid/12304053
https://dl.ndl.go.jp/pid/12304053
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-07-05T02:30:21+09:00
Date Created (W3CDTF): 2022-06-15
Format (IMT): PDF
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Related Material (URI): http://hdl.handle.net/10422/00013344
Periodical Title (URI): http://hdl.handle.net/10422/00013343
https://shiga-med.repo.nii.ac.jp/records/4258
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp