HEATR1, a novel interactor of Pontin/Reptin, stabilizes Pontin/Reptin and promotes cell proliferation of oral squamous cell carcinoma

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HEATR1, a novel interactor of Pontin/Reptin, stabilizes Pontin/Reptin and promotes cell proliferation of oral squamous cell carcinoma

Persistent ID (NDL): info:ndljp/pid/12313592

Material type: 博士論文

Author: Nakamura, Akihiko

Publisher: -

Publication date: 2022-03-23

Material Format: Digital

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Name of awarding university/degree: 新潟大学,博士（歯学）

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Note (General)：: Pontin and Reptin are closely related proteins belonging to the AAA+ (ATPases Associated with various cellular Activities) family. They form a hetero-...

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Material Type: 博士論文
Title: HEATR1, a novel interactor of Pontin/Reptin, stabilizes Pontin/Reptin and promotes cell proliferation of oral squamous cell carcinoma
Author/Editor: Nakamura, Akihiko
Author Heading: Nakamura, Akihiko
Publication Date: 2022-03-23
Publication Date (W3CDTF): 2022-03-23
Alternative Title: Pontin/Reptinの新規結合因子であるHEATR1は、Pontin/Reptinの安定化と口腔扁平上皮癌細胞の増殖促進に寄与する
Degree grantor/type: 新潟大学
Date Granted: 2022-03-23
Date Granted (W3CDTF): 2022-03-23
Dissertation Number: 甲第5027号
Degree Type: 博士（歯学）
Conferring No. (Dissertation): 甲第5027号
Text Language Code: eng
Alias of Author: 中村, 彬彦
Subject Heading: HEATR1
Pontin
Reptin
mTOR
Oral squamous cell carcinoma
Target Audience: 一般
Note (General): Pontin and Reptin are closely related proteins belonging to the AAA+ (ATPases Associated with various cellular Activities) family. They form a hetero-oligomeric complex, Pontin/Reptin, which is involved in protein stability and assembly of the protein complexes as a molecular chaperone. Overexpression of Pontin and Reptin in tumor cells has been reported and is implicated in the development of various cancers. However, the molecular mechanism of Pontin/Reptin function in oral squamous cell carcinoma (OSCC) development remains unclear. Here, we identify HEAT repeat-containing protein 1 (HEATR1) as a novel binding factor of Pontin/Reptin. Functionally, HEATR1 stabilizes Pontin/Reptin and positively regulates OSCC cell proliferation by activating mTOR and pre-rRNA synthesis. We also find that HEATR1 expression is markedly upregulated in tumor region of OSCC tissue. Hence, we propose that HEATR1 is involved in the regulation of mTOR and ribosome biogenesis as a potential protein stabilizer of Pontin/Reptin in OSCC.
Biochemical and Biophysical Research Communications. 2021, 557, 294-301.
新大院博(歯)第513号
Persistent ID (NDL): info:ndljp/pid/12313592
https://dl.ndl.go.jp/pid/12313592
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-08-08T06:02:54+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://hdl.handle.net/10191/0002000643
https://niigata-u.repo.nii.ac.jp/records/2000643
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp