Pregnancy outcomes and mid-term prognosis in women after arterial switch operation for dextro-transposition of the great arteries – Tertiary hospital experiences and review of literature

• Material Type: 博士論文
• Title: Pregnancy outcomes and mid-term prognosis in women after arterial switch operation for dextro-transposition of the great arteries – Tertiary hospital experiences and review of literature
• Author/Editor: Horiuchi, Chinami
• Author Heading: Horiuchi, Chinami
• Publication, Distribution, etc.: 三重大学
• Publication Date: 2022-03-25
• Publication Date (W3CDTF): 2022-03-25
• Degree grantor/type: 三重大学
• Date Granted: 2022-03-25
• Date Granted (W3CDTF): 2022-03-25
• Dissertation Number: 甲医学第2112号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲医学第2112号
• Text Language Code: eng
• Alias of Author: ホリウチ, チナミ; 堀内, 縁
• Subject Heading: Arterial switch operation; Congenital heart disease; Pregnancy; Dextro-transposition of the great arteries
• Target Audience: 一般
• Note (General): application/pdf; Objective: Arterial switch operation (ASO) for dextro-transposition of the great arteries (d-TGA) has gradually replaced the atrial switch operation and has become the standard operation. To date, the outcomes of pregnant women with d-TGA after this new operation have not been investigated. In this study, we investigated the impact of ASO on pregnant outcomes and mid-term prognosis in women with d-TGA and compared with the atrial switch operation through the literature review.Methods and results: There were 20 pregnancies in 10 women with d-TGA after ASO and 6 resulted in abortion. Among 14 successful pregnancies in 10 women, 11 pregnancies achieved the term delivery and 3 pregnancies, including 1 twin pregnancy, resulted in preterm labor. Maternal cardiovascular events occurred in 4 (heart failure and arrhythmias in 3 and arrhythmia in 1), and all were controllable with medications. Risk factors for the peripartum cardiac events were older age at ASO and delivery, and higher concentration of brain natriuretic peptide (BNP) at first trimester (p < 0.05). In 7–60 monthfollow-up after delivery, no case showed deterioration of functional class and systemic ventricular function. According to the literature review, women after ASO demonstrated a better prognosis than those after the atrial switch operation.Conclusions: The majority of women with d-TGA after ASO tolerated pregnancy and delivery well. The older age at ASO, an elderly pregnancy, and higher BNP levels at the first trimester were possibly risk factors of peripartum cardiovascular events among the group. The literature reviews and this study may indicate the advantage of systemic left ventricle compared with systemic right ventricle in long-term outcomes after delivery.; 本文/Departments of Perinatology and Gynecology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan; 8p
• DOI: info:doi/10.1016/j.jjcc.2018.11.007; https://doi.org/info:doi/10.1016/j.jjcc.2018.11.007
• Persistent ID (NDL): info:ndljp/pid/12313675; https://dl.ndl.go.jp/pid/12313675
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2022-08-08T06:02:54+09:00
• Date Created (W3CDTF): 2022-07-20
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10076/00020579; https://mie-u.repo.nii.ac.jp/records/14961
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp