Alternative Title十二指腸乳頭部腫瘍に対する内視鏡的乳頭部切除術後の再発予測因子
Periodical titleJournal of Hepato-Biliary-Pancreatic Sciences
Degree grantor/typeNagasaki University (長崎大学)
Note (General)Background/Purpose: Recurrence of ampullary neoplasms after endoscopic papil-lectomy (EP) has not been well elucidated. This study aimed to clarify the predictive factors for recurrences after EP. We also aimed to investigate the retreatment of the recurrent lesions and their outcomes.Methods: This multicenter, retrospective cohort study included 96 patients with am-pullary neoplasms who underwent EP at four tertiary centers between January 2000 and October 2018.Results: The pathological diagnoses of resected specimens confirmed adenoma in 62 and adenocarcinoma in 34 patients (six Tis, 24 T1a, three T1b, one inconclu-sive). Complete resection was confirmed for 79 patients (82.3%). Recurrent lesions were observed in 13 patients (13.5%) during a median follow- up of 3 months (1- 36 months) after EP. The predictive factors of recurrence were piecemeal resection, and non- negative horizontal or vertical margin in univariate analysis. Non- negative vertical margin was the only independent predictive factor of recurrence in the mul-tivariate analysis. The recurrent lesions were treated endoscopically in 11 patients. Recurrence after the endoscopic retreatments was observed in one patient.Conclusions: Complete resection with negative vertical margin is an important fac-tor in preventing the recurrence of ampullary neoplasms after EP. Endoscopic re-treatments are also feasible for recurrent lesions.
長崎大学学位論文 学位記番号:博(医歯薬)甲第1457号 学位授与年月日:令和4年6月1日
Author: Takahashi Kosuke, Ozawa Eisuke, Yasuda Ichiro, Komatsu Naohiro, Miyaaki Hisamitsu, Ohnita Ken, Yamao Takuji, Oba Kazuo, Ichikawa Tatsuki, Nakao Kazuhiko
Citation: Journal of Hepato-Biliary-Pancreatic Sciences, 28(7), pp.625-634; 2022
identifier:Nagasaki University (長崎大学), 博士(医学) (2022-06-01)
http://hdl.handle.net/10069/00041587
Collection (particular)国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
Date Accepted (W3CDTF)2022-08-08T06:02:54+09:00
Data Provider (Database)国立国会図書館 : 国立国会図書館デジタルコレクション