Microbiome analysis in women with endometriosis: does a microbiome exist in peritoneal fluid and ovarian cystic fluid?

• Material Type: 博士論文
• ISSN: 1445-5781
• Title: Microbiome analysis in women with endometriosis: does a microbiome exist in peritoneal fluid and ovarian cystic fluid?
• Volume: 21 1
• Author/Editor: 大石, 杉子
• Author Heading: 大石, 杉子
• Publication, Distribution, etc.: 琉球大学
• Publication Date: 2022-03-18
• Publication Date (W3CDTF): 2022-03-18
• Alternative Title: 子宮内膜症症例におけるマイクロバイオーム解析； 腹水と卵巣嚢腫内容液にマイクロバイオームは存在するのか？
• Periodical title: Reproductive Medicine and Biology
• Degree grantor/type: 琉球大学
• Date Granted: 2022-03-18
• Date Granted (W3CDTF): 2022-03-18
• Dissertation Number: 甲第540号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲第540号
• Text Language Code: eng
• Alias of Author: Oishi, Sugiko
• Subject Heading: 16S rRNA; endometriosis; microbiome; ovarian cystic fluid; peritoneal fluid
• Target Audience: 一般
• Note (General): Purpose: To investigate the relationship between the microbiome of the female genital tract and endometriosis.Methods: This prospective cohort study included 36 women who underwent laparoscopic surgery for ovarian tumor from July 2019 to April 2020. Of them, 18 had endometriosis, and 18 did not have endometriosis. Vaginal secretions, endometrial fluid, peritoneal fluid, and ovarian cystic fluid were collected during surgery. Next-generation sequencing of bacterial 16S rRNA was performed to characterize the microbiome.Results: Specific microbiomes were not detected in either peritoneal fluid or ovarian cystic fluid regardless of the presence or absence of endometriosis and the type of cyst. When the cutoff value of infectious bacterial abundance in the vagina was set as 64.3%, there were many cases more than a cutoff value in the endometriosis group significantly (p = 0.01). When the cutoff value of infectious bacterial abundance in the endometrium was set as 18.6%, there were many cases more than a cutoff level in the endometriosis cases significantly (p = 0.02).Conclusion: Peritoneal fluid and ovarian cystic fluid are almost sterile, although dysbiosis may occur in the vaginal and endometrial microbiome in women with endometriosis.
• Persistent ID (NDL): info:ndljp/pid/12314033; https://dl.ndl.go.jp/pid/12314033
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2022-08-08T06:02:54+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/20.500.12000/0002018034; https://u-ryukyu.repo.nii.ac.jp/records/2018034
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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