Three-month early change in prostate-specific antigen levels as a predictive marker for overall survival during hormonal therapy for metastatic hormone-sensitive prostate cancer

• Material Type: 博士論文
• ISSN: 1756-0500
• Title: Three-month early change in prostate-specific antigen levels as a predictive marker for overall survival during hormonal therapy for metastatic hormone-sensitive prostate cancer
• Volume: 14
• Author/Editor: 仲西, 昌太郎
• Author Heading: 仲西, 昌太郎
• Publication, Distribution, etc.: 琉球大学
• Publication Date: 2021-11-18
• Publication Date (W3CDTF): 2021-11-18
• Alternative Title: ホルモン感受性前立腺癌における、ホルモン治療開始3か月後のPSA値は全生存期間の予測マーカーである
• Periodical title: BMC Research Notes
• Degree grantor/type: 琉球大学
• Date Granted: 2021-11-18
• Date Granted (W3CDTF): 2021-11-18
• Dissertation Number: 甲第535号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲第535号
• Text Language Code: und
• Alias of Author: Nakanishi, Shotaro
• Subject Heading: mHSPC; Time to CRPC; Prostate cancer; 3-Month %PSA
• Target Audience: 一般
• Note (General): Objective: To date, there are no useful markers for predicting the prognosis of metastatic hormone-sensitive prostate cancer (mHSPC). We evaluated the effect of early changes in prostate-specific antigen (PSA) levels after androgen deprivation therapy (ADT) on castration-resistant prostate cancer (CRPC) progression and overall survival (OS) in mHSPC patients.<br/>Results: In 71 primary mHSPC patients treated with ADT, the median times to CRPC and OS were 15 months and 92 months, respectively. In multivariate analysis, a Gleason score of≥8 (p=0.004), an extent of disease value (EOD) of≥2 (p=0.004), and a 3-month PSA level>1% of the pretreatment level (p=0.017) were independent predictors of shorter time to CRPC. The area under the receiver operating characteristic curve was feasible at 0.822. A 3-month PSA level>1% of the pretreatment level was an independent predictor of OS (p=0.004). Three factors were independent predictors of shorter time to CRPC. A 3-month PSA level>1% of the pretreatment level correlated with a poor prognosis.
• Persistent ID (NDL): info:ndljp/pid/12314035; https://dl.ndl.go.jp/pid/12314035
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2022-08-08T06:02:54+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/20.500.12000/0002018027; https://u-ryukyu.repo.nii.ac.jp/records/2018027
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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