Macular Microvasculature and Associated Retinal Layer Thickness in Pediatric Amblyopia:Magnification-corrected Analyses （小児の弱視眼における黄斑部微小血管構造と網膜層厚：画像拡大率補正による解析） 3

• Material Type: 博士論文
• ISSN: 0146-0404
• Title: Macular Microvasculature and Associated Retinal Layer Thickness in Pediatric Amblyopia:Magnification-corrected Analyses （小児の弱視眼における黄斑部微小血管構造と網膜層厚：画像拡大率補正による解析）
• Volume: 62 3
• Author/Editor: 西川, 典子
• Author Heading: 西川, 典子
• Publication Date: 2021-03
• Publication Date (W3CDTF): 2021-03
• Periodical title: Investigative Ophthalmology and Visual Science
• Degree grantor/type: 旭川医科大学
• Date Granted: 2022-03-25
• Date Granted (W3CDTF): 2022-03-25
• Dissertation Number: 乙第492号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 乙第492号
• Text Language Code: eng
• Target Audience: 一般
• Note (General): type:application/pdf; Purpose: The purpose of this study was to characterize macular microvasculature and structural retinal layers using magnification-corrected optical coherence tomography angiography (OCTA) images in children with amblyopia.Methods: This prospective cross-sectional study included 22 children with unilateral amblyopia (4-11 years of age) receiving spectral-domain OCTA. Vessel densities in foveal and parafoveal regions of the superficial capillary plexus (SCP) and deep capillary plexus (DCP) were measured in amblyopic and fellow eyes using a customized image analysis program correcting the scale of retinal image with axial length. Iowa Reference Algorithms (Iowa Institute for Biomedical Imaging) were used to measure mean thickness values of 10 intra-retinal layers rescaled for image size correction.Results: Foveal and parafoveal vessel densities in amblyopic eyes were lower than that of the fellow eyes in the SCP (fovea: P = 0.006 and parafovea: P = 0.003) and the DCP (P = 0.024 and P = 0.025, respectively). Amblyopic eyes had significantly smaller foveal avascular zone (FAZ) area than fellow eyes (P < 0.001). There were significant differences in retinal layer thickness between paired eyes, particularly in the inner retina in both foveal and parafoveal regions; retinal nerve fiber layer (RNFL) (P = 0.024 and P = 0.095, respectively), ganglion cell layer (P < 0.001 and P = 0.008), inner plexiform layer (IPL; P = 0.12 and P = 0.037), inner nuclear layer (P = 0.005 and P = 0.005), and outer plexiform layer (OPL; P = 0.02 and P = 0.057), except in the foveal IPL, the parafoveal RNFL, and OPL.Conclusions: Unilateral amblyopic eyes demonstrate reduced macular vessel density and thicker inner retinal layers compared with fellow eyes even after correcting for image magnification. Changes in macular microvasculature and structural layers may offer valuable insights in the development of amblyopia.; identifier:PMID:33783486
• DOI: info:doi/10.1167/iovs.62.3.39; https://doi.org/info:doi/10.1167/iovs.62.3.39
• Persistent ID (NDL): info:ndljp/pid/12319251; https://dl.ndl.go.jp/pid/12319251
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2022-09-05T13:46:15+09:00
• Format (IMT): PDF
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): https://amcor.asahikawa-med.ac.jp/modules/xoonips/detail.php?id=20220325_O492
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp