Beneficial effects of end-ischemic oxygenated machine perfusion preservation for split-liver transplantation in recovering graft function and reducing ischemia-reperfusion injury （過小肝グラフトに対する短時間低温酸素化灌流保存の有効性の検討） 11 1

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Beneficial effects of end-ischemic oxygenated machine perfusion preservation for split-liver transplantation in recovering graft function and reducing ischemia-reperfusion injury （過小肝グラフトに対する短時間低温酸素化灌流保存の有効性の検討） 1

Persistent ID (NDL): info:ndljp/pid/12319254

Material type: 博士論文

Author: 石井, 大介

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Publication date: 2019-09

Material Format: Digital

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Name of awarding university/degree: 旭川医科大学,博士（医学）

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Note (General)：: type:application/pdfThis study examined the efficacy of end-ischemic hypothermic oxygenated machine perfusion preservation (HOPE) using an originally ...

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Material Type: 博士論文
ISSN: 2045-2322
Title: Beneficial effects of end-ischemic oxygenated machine perfusion preservation for split-liver transplantation in recovering graft function and reducing ischemia-reperfusion injury （過小肝グラフトに対する短時間低温酸素化灌流保存の有効性の検討）
Volume: 11 1
Author/Editor: 石井, 大介
Author Heading: 石井, 大介
Publication Date: 2019-09
Publication Date (W3CDTF): 2019-09
Periodical title: Scientific Reports
Degree grantor/type: 旭川医科大学
Date Granted: 2022-03-25
Date Granted (W3CDTF): 2022-03-25
Dissertation Number: 甲第575号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第575号
Text Language Code: eng
Target Audience: 一般
Note (General): type:application/pdf
This study examined the efficacy of end-ischemic hypothermic oxygenated machine perfusion preservation (HOPE) using an originally developed machine perfusion system for split-liver transplantation. Porcine split-liver grafts were created via 75% liver resection after 10 min of warm ischemia. In Group 1, grafts were preserved by simple cold storage (CS) for 8 h (CS group; n = 4). In Group 2, grafts were preserved by simple CS for 6 h and end-ischemic HOPE for 2 h (HOPE group; n = 5). All grafts were evaluated using an isolated ex vivo reperfusion model with autologous blood for 2 h. Biochemical markers (aspartate aminotransferase and lactate dehydrogenase levels) were significantly better immediately after reperfusion in the HOPE group than in the CS group. Furthermore, the HOPE group had a better histological score. The levels of inflammatory cytokines (tumor necrosis factor-α, interferon-γ, interleukin-1β, and interleukin-10) were significantly lower after reperfusion in the HOPE group. Therefore, we concluded that end-ischemic HOPE for split-liver transplantation can aid in recovering the graft function and reducing ischemia-reperfusion injury. HOPE, using our originally developed machine perfusion system, is safe and can improve graft function while attenuating liver injury due to preservation.
identifier:PMID:34799598
DOI: info:doi/10.1038/s41598-021-01467-0
https://doi.org/info:doi/10.1038/s41598-021-01467-0
Persistent ID (NDL): info:ndljp/pid/12319254
https://dl.ndl.go.jp/pid/12319254
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-09-05T13:46:15+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): https://amcor.asahikawa-med.ac.jp/modules/xoonips/detail.php?id=20220325_K575
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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