成人T細胞白血病(ATL)の治療に向けた新規抗CD70抗体薬物複合体の開発

• Material Type: 博士論文
• Title: 成人T細胞白血病(ATL)の治療に向けた新規抗CD70抗体薬物複合体の開発
• Author/Editor: 横田, 璃里
• Author Heading: 横田, 璃里
• Publication, Distribution, etc.: International Institute of Anticancer Research
• Publication Date: 2020-09-16
• Publication Date (W3CDTF): 2020-09-16
• Alternative Title: Novel Anti-CD70 Antibody Drug Conjugate for the Treatment of Adult T-Cell Leukemia (ATL)
• Degree grantor/type: 鹿児島大学
• Date Granted: 2020-09-16
• Date Granted (W3CDTF): 2020-09-16
• Dissertation Number: 甲総研第576号
• Degree Type: 博士(医学); Doctor of Philosophy in Medical Science
• Conferring No. (Dissertation): 甲総研第576号
• Text Language Code: eng
• Subject Heading: ATL; HTLV-1; antibody drug conjugate; cancer chemotherapy; Immunotherapy
• NDC: 490
• Target Audience: 一般
• Note (General): 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨; Background/Aim: Adult T-cell leukemia (ATL) is a hematological malignancy caused by infection with human T-cell leukemia virus type 1 (HTLV-1). Chemotherapy, antibody therapy, and bone marrow transplantation are used to treat this disease, however, median survival time has not been significantly improved. Our aim was to develop and evaluate a novel antibody-drug conjugate (ADC) with regards to cell cytotoxicity and target specificity. Materials and Methods: In this study, we have constructed a novel ADC, which is composed of an anti-CD70 single chain Fv-Fc antibody conjugated with the anticancer agent emtansine using a novel antibody modification method. Cell cytotoxicity and target specificity were assessed using a cell proliferation assay. Results: The anti-CD70 ADC selectively killed HTLV-1-infected cells and ATL cells without affecting other cells. Conclusion: The anti-CD70 ADC offers some chemotherapeutic potential for the treatment of ATL.RIRI YOKOTA, SHUN HASHIMOTO, IKUKO WATANABE, SATOSHI KISHIMOTO, MASAAKI TOYAMA, MIKA OKAMOTO, MAKOTO YOSHIMITSU, KENJI ISHITSUKA, YUJI ITO and MASANORI BABANovel Anti-CD70 Antibody Drug Conjugate for the Treatment of Adult T-Cell Leukemia (ATL)Anticancer Research 40(8): 4471-4479 (2020)https://doi.org/10.21873/anticanres.14452
• Persistent ID (NDL): info:ndljp/pid/12319694; https://dl.ndl.go.jp/pid/12319694
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2022-09-05T13:46:15+09:00
• Date Created (W3CDTF): 2020-10-05
• Format (IMT): PDF; application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10232/00031376
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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