Measurement of anti-suprabasin antibodies, multiple cytokines and chemokines as potential predictive biomarkers for neuropsychiatric systemic lupus erythematosus

• Material Type: 博士論文
• ISSN: 1521-6616
• Title: Measurement of anti-suprabasin antibodies, multiple cytokines and chemokines as potential predictive biomarkers for neuropsychiatric systemic lupus erythematosus
• Volume: 237
• Author/Editor: Hoang, Thi Thu Trang
• Author Heading: Hoang, Thi Thu Trang
• Publication, Distribution, etc.: Elsevier Inc.
• Publication Date: 2022-09-16
• Publication Date (W3CDTF): 2022-09-16
• Alternative Title: 抗suprabasin抗体、サイトカインおよびケモカインによる神経精神ループスの診断予測バイオマーカーの可能性
• Periodical title: Clinical Immunology
• Degree Grantor: Nagasaki University (長崎大学)
• Date Granted: 2022-09-16
• Date Granted (W3CDTF): 2022-09-16
• Dissertation Number: 甲共医歯薬第23号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲共医歯薬第23号
• Text Language Code: eng
• Subject Heading: Suprabasin; Cytokines; Chemokines; NPSLE; Bayesian posterior predictive values; SOIL
• Target Audience: 一般
• Note (General): Neuropsychiatric systemic lupus erythematosus (NPSLE) varies in presentation and is one of the leading causes of morbidity and mortality among patients with SLE. This study determined the most critical serum biomarkers for the development of NPSLE as they may have clinical utility prior to the onset of neuropsychiatric symptoms. We retrospectively analyzed 35 NPSLE patients, 34 SLE patients, 20 viral meningitis (VM) patients, and 16 relapsing-remitting multiple sclerosis (MS) patients. We measured anti-suprabasin antibodies concentrations in serum by using Luciferase immunoprecipitation system (LIPS) assay. The serum concentrations of cytokines/chemokines were measured by using multiplex bead-based assay. We found serum FGF-2 level was significantly higher in the NPSLE group compared to the SLE group and the healthy control group. The anti-suprabasin antibody relative concentration (SRC) has high positive predictive values for the development of NPSLE. The most essential biomarkers are VEGF, anti-suprabasin antibodies, sCD40L, IL-10, GRO, MDC, IL-8, IL-9, TNF-α, MIP-1α.; 長崎大学学位論文 学位記番号:共博(医歯薬)甲第23号 学位授与年月日:令和4年9月16日; Author: Trang T.T. Hoang, Kunihiro Ichinose, Shimpei Morimoto, Kaori Furukawa, Ly H.T. Le, Atsushi Kawakami; Citation: Clinical Immunology, 237, art.no.108980; 2022; identifier:Nagasaki University (長崎大学), 博士(医学) (2022-09-16); http://hdl.handle.net/10069/41579
• DOI: info:doi/10.1016/j.clim.2022.108980; https://doi.org/info:doi/10.1016/j.clim.2022.108980
• Persistent ID (NDL): info:ndljp/pid/12354460; https://dl.ndl.go.jp/pid/12354460
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2022-10-11T11:55:44+09:00
• Date Created (W3CDTF): 2022-09-29
• Format (IMT): PDF
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Related Material (URI): http://hdl.handle.net/10069/41579
• Periodical Title (URI): http://hdl.handle.net/10069/00041754
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp