Hypothermic circulatory arrest does not induce coagulopathy in vitro （in vitroモデルにおいて低体温循環停止法は凝固異常を惹起しない）

• Material Type: 博士論文
• Title: Hypothermic circulatory arrest does not induce coagulopathy in vitro （in vitroモデルにおいて低体温循環停止法は凝固異常を惹起しない）
• Author/Editor: 伊勢, 隼人
• Author Heading: 伊勢, 隼人
• Publication Date: 2022-03
• Publication Date (W3CDTF): 2022-03
• Periodical title: Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs
• Degree grantor/type: 旭川医科大学
• Date Granted: 2022-06-30
• Date Granted (W3CDTF): 2022-06-30
• Dissertation Number: 甲第580号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第580号
• Text Language Code: eng
• Subject Heading: Bleeding; Cardiopulmonary bypass; Coagulopathy; Hypothermic circulatory arrest; In vitro study
• Target Audience: 一般
• Note (General): type:application/pdf; Hypothermic circulatory arrest (HCA) is an essential procedure during aortic surgery to protect organs; however, hypothermia is believed to cause coagulopathy, which is a major fatal complication. This study aimed to clarify the impact of hypothermia on coagulation by eliminating clinical biases in vitro. In the hypothermic storage study, blood samples from five healthy volunteers were stored at 37 ℃ (group N) for 3 h or at 20 ℃ for 2 h, followed by 1 h of rewarming at 37 ℃ (group H). Thromboelastography was performed before and after 3 h of storage. In the mock circulation loop (MCL) study, blood samples were placed in the MCL and (a) maintained at 37 ℃ for 4 h (group N, n = 5), or (b) cooled to 20 ℃ to simulate HCA with a 0.1 L/min flow rate for 3 h and then rewarmed to 37 ℃ (group H, n = 5). The total MCL duration was 4 h, and the flow rate was maintained at 1 L/min, except during HCA. Blood samples collected 15 min after the beginning and end of MCL were subjected to standard laboratory tests and rotational thromboelastometry analyses. Hypothermia had no impact on coagulation in both the hypothermic storage and MCL studies. MCL significantly decreased the platelet counts and clot elasticity in the INTEM and EXTEM assays; however, there was no effect on fibrinogen contribution measured by FIBTEM. Hypothermia does not cause irreversible coagulopathy in vitro; however, MCL decreases coagulation due to the deterioration of platelets; identifier:PMID:35303203
• DOI: info:doi/10.1007/s10047-022-01324-5; https://doi.org/info:doi/10.1007/s10047-022-01324-5
• Persistent ID (NDL): info:ndljp/pid/12356120; https://dl.ndl.go.jp/pid/12356120
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2022-10-11T11:55:44+09:00
• Format (IMT): PDF
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): https://amcor.asahikawa-med.ac.jp/modules/xoonips/detail.php?id=20220630_K580
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp