Impact of valvuloarterial impedance on left ventricular reverse remodeling after aortic valve neocuspidization

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Impact of valvuloarterial impedance on left ventricular reverse remodeling after aortic valve neocuspidization

Persistent ID (NDL): info:ndljp/pid/12361047

Material type: 博士論文

Author: Yamamoto, Naoki

Publisher: 三重大学

Publication date: 2022-07-20

Material Format: Digital

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Name of awarding university/degree: 三重大学,博士(医学)

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Note (General)：: application/pdfBackground: Aortic valve neocuspidization (AVNeo) has emerged as a promising aortic valve procedure, and is expected to have a larger e...

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Material Type: 博士論文
Title: Impact of valvuloarterial impedance on left ventricular reverse remodeling after aortic valve neocuspidization
Author/Editor: Yamamoto, Naoki
Author Heading: Yamamoto, Naoki
Publication, Distribution, etc.: 三重大学
Publication Date: 2022-07-20
Publication Date (W3CDTF): 2022-07-20
Degree grantor/type: 三重大学
Date Granted: 2022-07-20
Date Granted (W3CDTF): 2022-07-20
Dissertation Number: 甲医学第2144号
Degree Type: 博士(医学)
Conferring No. (Dissertation): 甲医学第2144号
Text Language Code: eng
Alias of Author: ヤマモト, ナオキ
山本, 直樹
Subject Heading: Aortic valve neocuspidization
Aortic valve stenosis
Left ventricular geometry
Left ventricular reverse remodeling
Valvuloarterial impedance
Target Audience: 一般
Note (General): application/pdf
Background: Aortic valve neocuspidization (AVNeo) has emerged as a promising aortic valve procedure, and is expected to have a larger effective orifice area (EOA) than commercially available bioprostheses. It is, however, unclear which indices could facilitate left ventricular (LV) reverse remodeling after AVNeo. The aim of this study is to verify the impact of global left ventricular afterload on the LV reverse remodeling following AVNeo.Methods: Data-available consecutive 38 patients (median age, 77; interquartile range, 72.8–82.0) undergoing AVNeo for severe aortic stenosis were enrolled in this study. Preoperative and the last follow-up echocardiographic data were retrospectively analyzed including the valvuloarterial impedance (Zva), a marker of global LV afterload. Reduction in LV geometry index (LVGI) and relative wall thickness (RWT) were used as an indicator for LV reverse remodeling.Results: The Zva reduced in 24 patients (63.2%) during the follow-up period (median, 12 months). Reduction in Zva significantly correlated to improvement of LV geometry (LVGI (r = 0.400, p = 0.013) and RWT (r = 0.627, p < 0.001)),whereas increase in EOA index did not significantly correlate to LVGI (r = 0.009, p = 0.957), or RWT (r = 0.105, p = 0.529)). The reduction in Zva was the multivariate predictor of LV reverse remodeling.Conclusions: Low global LV afterload led to significant LV reverse remodeling even after AVNeo, which could achieve better valve performance than the conventional bioprostheses.
本文/Department of Thoracic and Cardiovascular Surgery, Mie University Hospital, 2‑174 Edobashi, Tsu City, Mie 514‑8507, Japan
9p
DOI: info:doi/10.1186/s13019-022-01760-7
https://doi.org/info:doi/10.1186/s13019-022-01760-7
Persistent ID (NDL): info:ndljp/pid/12361047
https://dl.ndl.go.jp/pid/12361047
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-11-07T16:56:35+09:00
Date Created (W3CDTF): 2022-10-24
Format (IMT): PDF
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://hdl.handle.net/10076/00020850
https://mie-u.repo.nii.ac.jp/records/15232
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp