Glycyrrhizin Attenuates Carcinogenesis by Inhibiting the Inflammatory Response in a Murine Model of Colorectal Cancer

• Material Type: 博士論文
• Title: Glycyrrhizin Attenuates Carcinogenesis by Inhibiting the Inflammatory Response in a Murine Model of Colorectal Cancer
• Author/Editor: Wang, Guifeng
• Author Heading: Wang, Guifeng
• Publication, Distribution, etc.: 三重大学
• Publication Date: 2022-07-20
• Publication Date (W3CDTF): 2022-07-20
• Degree grantor/type: 三重大学
• Date Granted: 2022-07-20
• Date Granted (W3CDTF): 2022-07-20
• Dissertation Number: 甲医学第2136号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲医学第2136号
• Text Language Code: eng
• Alias of Author: オウ, ケイホウ; 王, 桂鳳
• Subject Heading: colon cancer; Glycyrrhizin; COX-2; HMGB1; 8-NitroG; 8-OxodG; YAP1; SOX9
• Target Audience: 一般
• Note (General): application/pdf; Glycyrrhizin (GL), an important active ingredient of licorice root, which weakens the proinflammatory effects of high-mobility group box 1 (HMGB1) by blocking HMGB1 signaling. In this study, we investigated whether GL could suppress inflammation and carcinogenesis in an azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced murine model of colorectal cancer. ICR mice were divided into four groups (n = 5, each)—control group, GL group, colon cancer (CC) group, and GL-treated CC (CC + GL) group, and sacrificed after 20 weeks. Plasma levels of interleukin (IL)-6 and tumor necrosis factor (TNF)-αwere measured using an enzyme-linked immunosorbent assay. The colonic tissue samples were immunohistochemically stained with DNA damage markers (8-nitroguanine and 8-oxo-7, 8-dihydro-2’-deoxy-guanosine), inflammatory markers (COX-2 and HMGB1), and stem cell markers (YAP1 and SOX9). The average number of colonic tumors and the levels of IL-6 and TNF-α in the CC + GL group were significantly lower than those in the CC group. The levels of all inflammatory and cancer markers were significantly reduced in the CC + GL group. These results suggest that GL inhibits the inflammatory response by binding HMGB1, thereby inhibiting DNA damage and cancer stem cell proliferation and dedifferentiation. In conclusion, GL significantly attenuates the pathogenesis of AOM/DSS-induced colorectal cancer by inhibiting HMGB1-TLR4-NF-κB signaling.; 本文/Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan; 16p
• DOI: info:doi/10.3390/ijms22052609; https://doi.org/info:doi/10.3390/ijms22052609
• Persistent ID (NDL): info:ndljp/pid/12361053; https://dl.ndl.go.jp/pid/12361053
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2022-11-07T16:56:35+09:00
• Date Created (W3CDTF): 2022-10-24
• Format (IMT): PDF
• Access Restrictions: 国立国会図書館内限定公開
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• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10076/00020844; https://mie-u.repo.nii.ac.jp/records/15226
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp