Effects of amelogenin peptide derived from enamel matrix derivative on human dental pulp stem cells

Persistent ID (NDL): info:ndljp/pid/12361271

Material type: 博士論文

Author: 中野, 裕司

Publisher: -

Publication date: 2022-09-28

Material Format: Digital

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Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: Dental pulp stem cells (DPSCs) play an important role in the homeostasis of the pulp tissue and have a high potential for osteogenic differentiation. ...

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Material Type: 博士論文
Title: Effects of amelogenin peptide derived from enamel matrix derivative on human dental pulp stem cells
Author/Editor: 中野, 裕司
Author Heading: 中野, 裕司
Publication Date: 2022-09-28
Publication Date (W3CDTF): 2022-09-28
Alternative Title: ヒト歯髄幹細胞に対するエナメルマトリックスデリバティブ由来アメロジェニンペプチドの影響
Degree grantor/type: 大阪歯科大学
Date Granted: 2022-09-28
Date Granted (W3CDTF): 2022-09-28
Dissertation Number: 乙第1642号
Degree Type: 博士（歯学）
Conferring No. (Dissertation): 乙第1642号
Text Language Code: eng
Subject Heading: Enamel matrix derivative
Amelogenin
Dental pulp stem cells
Target Audience: 一般
Note (General): Dental pulp stem cells (DPSCs) play an important role in the homeostasis of the pulp tissue and have a high potential for osteogenic differentiation. Enamel matrix derivative (EMD) has been used in periodontal regeneration therapy. Previously, we designed a synthetic amelogenin peptide (AP) derived from EMD. In this study, we investigated the effects of AP on DPSCs and evaluated its usefulness as a dental pulp capping material. DPSCs were cultured in medium supplemented with AP (0 and 100 ng/ml) to examine the effect of DPSCs on cell morphology and the cell migration ability. In addition, DPSCs were cultured with osteogenic medium supplemented with AP at 0 and 100 ng/ml, and their osteogenic differentiation was examined by Alizarin Red staining. AP promoted cell extension by altering cell morphology, and also significantly promoted DPSCs chemotaxis and cell migration. Moreover, the number of calcified nodule formations stained by Alizarin Red increased in the AP group. In summary, AP may be useful as a dental pulp capping material.
2022年度
Persistent ID (NDL): info:ndljp/pid/12361271
https://dl.ndl.go.jp/pid/12361271
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-11-07T16:56:35+09:00
Date Created (W3CDTF): 2022-10-12
Format (IMT): PDF
Access Restrictions: 国立国会図書館内限定公開
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Availability of remote photoduplication service: 可
Periodical Title (URI): http://id.nii.ac.jp/1392/00000318/
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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