Ninjurin1 deletion in neuron-glial antigen 2-positive pericytes prevents microvessel maturation and delays wound healing （Neuron-glial antigen 2 陽性周細胞におけるNinjurin1の欠損は微小血管の成熟化を抑制し創傷治癒を遅延させる） 2 6

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Ninjurin1 deletion in neuron-glial antigen 2-positive pericytes prevents microvessel maturation and delays wound healing （Neuron-glial antigen 2 陽性周細胞におけるNinjurin1の欠損は微小血管の成熟化を抑制し創傷治癒を遅延させる） 6

Persistent ID (NDL): info:ndljp/pid/12361310

Material type: 博士論文

Author: 松尾, 梨沙

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Publication date: 2022-07

Material Format: Digital

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Name of awarding university/degree: 旭川医科大学,博士（医学）

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Note (General)：: type:application/pdfThe formation of mature vasculature through angiogenesis is essential for adequate wound healing, such that blood-borne cells, nut...

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Material Type: 博士論文
Title: Ninjurin1 deletion in neuron-glial antigen 2-positive pericytes prevents microvessel maturation and delays wound healing （Neuron-glial antigen 2 陽性周細胞におけるNinjurin1の欠損は微小血管の成熟化を抑制し創傷治癒を遅延させる）
Volume: 2 6
Author/Editor: 松尾, 梨沙
Author Heading: 松尾, 梨沙
Publication Date: 2022-07
Publication Date (W3CDTF): 2022-07
Periodical title: JID innovations : skin science from molecules to population health.
Degree grantor/type: 旭川医科大学
Date Granted: 2022-09-30
Date Granted (W3CDTF): 2022-09-30
Dissertation Number: 甲第582号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第582号
Text Language Code: eng
Subject Heading: 3D
three-dimensional; EC
keratinocyte; KO
knockout; Ninj1
Ninjurin-1; PC
pericyte; Tam
tamoxifen; VSMC
vascular smooth muscle cell; WT
wild-type
Target Audience: 一般
Note (General): type:application/pdf
The formation of mature vasculature through angiogenesis is essential for adequate wound healing, such that blood-borne cells, nutrients, and oxygen can be delivered to the remodeling skin area. Neovessel maturation is highly dependent on the coordinated functions of vascular endothelial cells and perivascular cells, namely pericytes (PCs). However, the underlying mechanism for vascular maturation has not been completely elucidated, and its role in wound healing remains unclear. In this study, we investigated the role of Ninjurin-1 (Ninj1), a new molecule mediating vascular maturation, in wound healing using an inducible PC-specific Ninj1 deletion mouse model. Ninj1 expression increased temporarily in NG2-positive PCs in response to skin injury. When tamoxifen treatment induced a decreased Ninj1 expression in PCs, the neovessels in the regenerating wound margins were structurally and functionally immature, but the total number of microvessels was unaltered. This phenotypic change is associated with a reduction in PC-associated microvessels. Wound healing was significantly delayed in the NG2-specific Ninj1 deletion mouse model. Finally, we showed that Ninj1 is a crucial molecule that mediates vascular maturation in injured skin tissue through the interaction of vascular endothelial cells and PCs, thereby inducing adequate and prompt wound healing.
identifier:PMID:36262667
DOI: info:doi/10.1016/j.xjidi.2022.100141
https://doi.org/info:doi/10.1016/j.xjidi.2022.100141
Persistent ID (NDL): info:ndljp/pid/12361310
https://dl.ndl.go.jp/pid/12361310
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-11-07T16:56:35+09:00
Format (IMT): PDF
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): https://amcor.asahikawa-med.ac.jp/modules/xoonips/detail.php?id=20220930_K582
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp