Hypothermia cannot ameliorate renal fibrosis after asphyxia in the newborn piglet

The cover of this title could differ from library to library.

Available in National Diet Library

Find on the publisher's website

国立国会図書館デジタルコレクション

Digital data available

Check on the publisher's website

DOI[info:doi/10.1111/ped.14961]to the data of the same series

Hypothermia cannot ameliorate renal fibrosis after asphyxia in the newborn piglet

Persistent ID (NDL): info:ndljp/pid/12361440

Material type: 博士論文

Author: 若林, 誉幸

Publisher: -

Publication date: 2021-12-27

Material Format: Digital

Capacity, size, etc.: -

Name of awarding university/degree: 香川大学,博士（医学）

View All

Notes on use at the National Diet Library

本資料は、掲載誌(URI)等のリンク先にある学位授与機関のWebサイトやCiNii Dissertationsから、本文を自由に閲覧できる場合があります。

Notes on use

Note (General)：: Background: The effects of therapeutic hypothermia (TH) on renal function are not widely reported, especially in longer-term animal models. The hypoth...

Search by Bookstore

Bibliographic Record

You can check the details of this material, its authority (keywords that refer to materials on the same subject, author's name, etc.), etc.

Digital

Material Type: 博士論文
Title: Hypothermia cannot ameliorate renal fibrosis after asphyxia in the newborn piglet
Author/Editor: 若林, 誉幸
Author Heading: 若林, 誉幸
Publication Date: 2021-12-27
Publication Date (W3CDTF): 2021-12-27
Alternative Title: 低体温療法は新生仔豚における仮死後の腎線維化を改善させることが出来ない
Degree grantor/type: 香川大学
Date Granted: 2021-12-27
Date Granted (W3CDTF): 2021-12-27
Dissertation Number: 甲第789号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第789号
Text Language Code: eng
Alias of Author: Wakabayashi, Takayuki
Subject Heading: Asphyxia
hypothermia
newborn
piglet
renal fibrosis
Target Audience: 一般
Note (General): Background: The effects of therapeutic hypothermia (TH) on renal function are not widely reported, especially in longer-term animal models. The hypothesis of this study was that TH of the kidneys of hypoxic-ischemic newborn piglets would reduce pathological renal fibrosis.
Methods: Twenty-five newborn piglets obtained within 24 h of birth were classified into a Control group (n = 5), hypoxic insult with normothermia (HI-NT) group (n = 12), and hypoxic insult with TH (HI-TH) group (33.5°C ± 0.5°C for 24 h; n = 8). Five days after the insult, all piglets were sacrificed under deep anesthesia by isoflurane inhalation. The kidneys were perfused with phosphate-buffered paraformaldehyde and immersed in formalin buffer. Territory fibrosis was studied and scored in the renal medulla using Azan staining.
Results: Fibrosis area scores (mean ± standard deviation) based on Azan staining were 1.00 ± 0.46 in the Control group, 2.85 ± 0.93 in the HI-NT group, and 3.58 ± 1.14 in the HI-TH group. The fibrosis area of the HI-NT and HI-TH groups was larger than that of the Control. The HI-NT and HI-TH groups were not statistically different.
Conclusion: Renal fibrosis is affected by perinatal asphyxia and cannot be prevented by TH, based on histopathological findings.
DOI: info:doi/10.1111/ped.14961
https://doi.org/info:doi/10.1111/ped.14961
Persistent ID (NDL): info:ndljp/pid/12361440
https://dl.ndl.go.jp/pid/12361440
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-11-07T16:56:35+09:00
Date Created (W3CDTF): 2022-01-14
Format (IMT): PDF
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): https://kagawa-u.repo.nii.ac.jp/records/8893
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp