Alternative Title小児期における先天性心疾患患児の脳ヘモグロビン酸素飽和度の有用性
Note (General)Background: It is important to identify the pathological characteristics of cerebral circulation and oxygen metabolism at the bedside in children with congenital heart disease (CHD) to prevent neurodevelopmental impairments. The brain regional oxygen saturation index (rSO2 ) can be easily obtained at the bedside with near-infrared spectroscopy and has been widely used in the management of children with CHD in recent years.
Methods: To determine if the rSO2 before or after CHD surgery is a good predictor of cerebral oxygen metabolism, we investigated the impact of different clinical variables on the correlation between rSO2 and reference values under steady ratios of hemoglobin oxygen saturation in the internal jugular vein (SjvO2 ) or femoral artery (SaO2 ) (0.75:0.25, 0.66:0.34, and 0.50:0.50) in 186 children with CHD undergoing cardiac catheterization.
Results: In three patient groups-double ventricles before surgery, double ventricles after surgery, and single ventricle before surgery-there were significant relationships between rSO2 and the reference values of SO2 under all three steady ratios of SjvO2 and SaO2 . No relationship with the reference values was found for the single ventricle after surgery group.
Conclusions: rSO2 is useful for assessing cerebral oxygenation in children with CHD, but knowledge of the underlying cardiac pathology in CHD, especially in the case of a single ventricle after surgery, is important for the correct interpretation of rSO2 measurements obtained using near-infrared spectroscopy.
Collection (particular)国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
Date Accepted (W3CDTF)2022-11-07T16:56:35+09:00
Data Provider (Database)国立国会図書館 : 国立国会図書館デジタルコレクション