Behavioral and Immunohistochemical Evidence for Suppressive Effects of Goshajinkigan on Salicylate-Induced Tinnitus in Rats.

• Material Type: 博士論文
• Title: Behavioral and Immunohistochemical Evidence for Suppressive Effects of Goshajinkigan on Salicylate-Induced Tinnitus in Rats.
• Author/Editor: Kitano, Koichi; Yamashita, Akinori; Sugimura, Taketoshi; Okayasu, Tadao; Sakagami, Masaharu; Osaki, Daisuke; Kitahara, Tadashi; Saito, Yasuhiko
• Author Heading: Kitano, Koichi; Yamashita, Akinori; Sugimura, Taketoshi; Okayasu, Tadao; Sakagami, Masaharu; Osaki, Daisuke; Kitahara, Tadashi; Saito, Yasuhiko
• Publication, Distribution, etc.: MDPI
• Publication Date: 2022-04-30; 12 5
• Publication Date (W3CDTF): 2022-04-30
• Alternative Title: サリチル酸誘発耳鳴に対する牛車腎気丸の抑制効果の行動学的および免疫組織化学的な根拠
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2022-09-28
• Date Granted (W3CDTF): 2022-09-28
• Dissertation Number: 甲第851号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: tinnitus; salicylate; animal mode; Kampo; goshajinkigan; c-Fos; rat
• Target Audience: 一般
• Note (General): type:Thesis; Many people are affected by tinnitus, a sensation of ringing in the ear despite the absence of external sound. Goshajinkigan (GJG) is one of the formulations of Japanese traditional herbal medicine and is prescribed for the palliative treatment of patients with tinnitus. Although GJG is clinically effective in these patients, its behavioral effects and the underlying neuroanatomical substrate have not been modeled in animals. We modeled tinnitus using salicylate-treated rats, demonstrated the effectiveness of GJG on tinnitus, and examined the underlying neuronal substrate with c-Fos expression. Intraperitoneal injection of sodium salicylate (400 mg/kg) into rats for three consecutive days significantly increased false positive scores, which were used to assess tinnitus behavior. When GJG was orally administered one hour after each salicylate injection, the increase in tinnitus behavior was suppressed. The analysis of c-Fos expression in auditory-related brain areas revealed that GJG significantly reduced the salicylate-induced increase in the number of c-Fos-expressing cells in the auditory cortices, inferior colliculus, and dorsal cochlear nucleus. These results suggest a suppressive effect of GJG on salicylate-induced tinnitus in animal models.; 博士（医学）・甲第851号・令和4年9月28日; Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).; identifier:Brain sciences Vol.12 No.5 Article No.587 (2022 Apr); identifier:20763425; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/4078; identifier:Brain sciences, 12(5): Article No.587
• Persistent ID (NDL): info:ndljp/pid/12510419; https://dl.ndl.go.jp/pid/12510419
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• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2023-01-30T13:49:41+09:00
• Format (IMT): application/pdf
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• Periodical Title (URI): http://hdl.handle.net/10564/4078
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