Efficacy of combined hand exercise intervention in patients with chemotherapy-induced peripheral neuropathy: a pilot randomized controlled trial

• Material Type: 博士論文
• Title: Efficacy of combined hand exercise intervention in patients with chemotherapy-induced peripheral neuropathy: a pilot randomized controlled trial
• Author/Editor: 壱岐尾, 優太
• Author Heading: 壱岐尾, 優太
• Publication, Distribution, etc.: Springer Nature
• Publication Date: 2022-06-01
• Publication Date (W3CDTF): 2022-06-01
• Alternative Title: 化学療法誘発性末梢神経障害患者に対する複合的な手指運動介入の有効性：パイロットランダム化比較試験
• Degree grantor/type: Nagasaki University (長崎大学)
• Date Granted: 2022-06-01
• Date Granted (W3CDTF): 2022-06-01
• Dissertation Number: 甲医歯薬第1459号
• Degree Type: 博士(医学)
• Text Language Code: eng
• Subject Heading: Chemotherapy; Peripheral neuropathy; Hand exercise; Upper-extremity function
• Target Audience: 一般
• Note (General): Purpose Previous evidence regarding the impact of exercise interventions on chemotherapy-induced peripheral neuropathy often focuses on lower-extremity functions, such as muscle strength and balance ability, while their efects on upper extremities remain unknown. We aimed to evaluate the efcacy of combined hand exercise intervention on upper-extremity function, symptoms, and quality-of-life in patients with chemotherapy-induced peripheral neuropathy (CIPN). Methods After screening 341 patients, 42 were randomly assigned to either the intervention (n=21) or control (n=21) group. Participants were evaluated at baseline (T0) and after one (T1) and two (T2) chemotherapy cycles. The primary outcome was upper-extremity function measured using the Michigan Hand Outcomes Questionnaire (MHQ) at T2. The intention-to-treat and as-treated populations were compared using a mixed-efect model. Results In the intention-to-treat analysis, the decline in activities of daily living of MHQ was signifcantly suppressed in the intervention group compared with that in the control group at T2 (diference: 7.23; 95% confdence interval: 0.35–14.10). Similarly, in the as-treated analysis, the decline in activities of daily living of MHQ was signifcantly suppressed in the intervention group compared with that in the control group at T2 (diference: 13.09; 95% confdence interval: 5.68–20.49). Pain also signifcantly improved in the intervention group compared with that in the control group at T2 (diference: 13.21; 95% confdence interval:−22.91 to−3.51). Conclusion The combined hand exercise intervention may improve upper-extremity function, such as by suppressing decline in ADL, and reduce pain in patients with CIPN.; 長崎大学学位論文 学位記番号:博(医歯薬)甲第1459号 学位授与年月日:令和4年6月1日; Author: Yuta Ikio, Akira Sagari, Akira Nakashima, Daiki Matsuda, Terumitsu Sawai, Toshio Higashi; Citation: Supportive Care in Cancer, 30, pp.4981-4992; 2022; identifier:Nagasaki University (長崎大学), 博士(医学) (2022-06-01); http://hdl.handle.net/10069/00041589
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• Date Accepted (W3CDTF): 2023-03-02T11:18:09+09:00
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• Periodical Title (URI): http://hdl.handle.net/10069/00041623
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